ID   MALT_PHOLL              Reviewed;         904 AA.
AC   Q7N976;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
DE   AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
GN   Name=malT {ECO:0000255|HAMAP-Rule:MF_01247}; OrderedLocusNames=plu0471;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Positively regulates the transcription of the maltose regulon
CC       whose gene products are responsible for uptake and catabolism of malto-
CC       oligosaccharides. Specifically binds to the promoter region of its
CC       target genes, recognizing a short DNA motif called the MalT box.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are both
CC       required for DNA binding. {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in the
CC       presence of the positive effectors ATP and maltotriose.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SIMILARITY: Belongs to the MalT family. {ECO:0000255|HAMAP-
CC       Rule:MF_01247}.
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DR   EMBL; BX571860; CAE12766.1; -; Genomic_DNA.
DR   RefSeq; WP_011144857.1; NC_005126.1.
DR   AlphaFoldDB; Q7N976; -.
DR   SMR; Q7N976; -.
DR   STRING; 243265.plu0471; -.
DR   PRIDE; Q7N976; -.
DR   EnsemblBacteria; CAE12766; CAE12766; plu0471.
DR   GeneID; 24168184; -.
DR   KEGG; plu:plu0471; -.
DR   eggNOG; COG2909; Bacteria.
DR   HOGENOM; CLU_006325_3_0_6; -.
DR   OMA; SDWVSNA; -.
DR   OrthoDB; 1377603at2; -.
DR   BioCyc; PLUM243265:PLU_RS02300-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01247; HTH_type_MalT; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Carbohydrate metabolism; DNA-binding;
KW   Nucleotide-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..904
FT                   /note="HTH-type transcriptional regulator MalT"
FT                   /id="PRO_0000184166"
FT   DOMAIN          832..897
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   DNA_BIND        856..875
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
SQ   SEQUENCE   904 AA;  103872 MW;  84FC3A19038FF779 CRC64;
     MLIPSKLSRP VRLNNTVLRE RLLIRLNESS NYRLVLITSP AGYGKTTLVS QWAAGQDNLG
     WYSLDESDNQ PERFASYLIA ALQQATQGHC VKSEVLAQKH QYANLPALFA QLFIELSEWR
     RPIFLVIDDY HLIVNNMIHE AMRFFLRHQP ENLTLTILSR NLPSLGVANL RVREQLLEID
     SQQLAFDYQE TQQFFDKRLT TSLDADDCKR LCNEVAGWAT ALQLIALSAR QSCDAAELSA
     KRLSGINAGH LSDYLVDEVL NQVGSSTREF LLRSSILRSM NDGLIVRLTG EENGQQRLEE
     TERQGLFIQR MDDSGEWFRF HPLFASFLRQ RCQWEMALQL PELHRAAAEG WLAQGYPGEA
     IHHALAAGDT AMLRDILLQH AWSLFNHSEL SLLEECMNAL PYEQLLESPR LVLLQAWLAQ
     SQHRYSEVNT LLNQAEQALQ QKQIAIEPDL LAEFDALRAQ VAMNSGKPEM ADKLAKQALA
     ALLPQNEYSR IVATSVEGEV LHCRGELADA LARMQQTEQL ARRFHVHHYA LWALLQQSEI
     LLAQGYLQTA YETQNKAFEL IREQHLEQLP MHEFLLRIRS QLLWCWSRLD EAEEAARRGL
     EVLSNFQPQQ QLQCLTQLAK CSLTRGDIDN ARRYLARCEN LLSNGQYHRD WRTNTDKLRV
     IIWQSMDDKS AAIRWLAQTE RPESVSNHFN QGQWRNIARA QILLGLYDEA ESILDTLNQH
     ARELQLISDL NRNLLLCNLL YWHIGRKSEA QSALIEALSL ANRTGFISHF VIEGELMAQQ
     LRQLIQLNTL SELELHRAQR ILRDINRQHR HKFAHFDESF VTQLLTHPDV PELIRNSPLT
     QREWQVLGLI YSGYSNDQIA AELDVATTTI KTHIRNLYQK LGIANRQEAI QQAQQLMQMM
     GLGV