ID   MALT_VIBC1              Reviewed;         902 AA.
AC   A7N5N6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
DE   AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
GN   Name=malT {ECO:0000255|HAMAP-Rule:MF_01247};
GN   OrderedLocusNames=VIBHAR_04848;
OS   Vibrio campbellii (strain ATCC BAA-1116).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=2902295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1116 / BB120;
RG   The Vibrio harveyi Genome Sequencing Project;
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K.,
RA   Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates the transcription of the maltose regulon
CC       whose gene products are responsible for uptake and catabolism of malto-
CC       oligosaccharides. Specifically binds to the promoter region of its
CC       target genes, recognizing a short DNA motif called the MalT box.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are both
CC       required for DNA binding. {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in the
CC       presence of the positive effectors ATP and maltotriose.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SIMILARITY: Belongs to the MalT family. {ECO:0000255|HAMAP-
CC       Rule:MF_01247}.
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DR   EMBL; CP000790; ABU72756.1; -; Genomic_DNA.
DR   RefSeq; WP_011999152.1; NC_022270.1.
DR   AlphaFoldDB; A7N5N6; -.
DR   SMR; A7N5N6; -.
DR   PRIDE; A7N5N6; -.
DR   EnsemblBacteria; ABU72756; ABU72756; VIBHAR_04848.
DR   KEGG; vha:VIBHAR_04848; -.
DR   PATRIC; fig|338187.25.peg.5341; -.
DR   OMA; SDWVSNA; -.
DR   OrthoDB; 1377603at2; -.
DR   Proteomes; UP000008152; Chromosome II.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01247; HTH_type_MalT; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Carbohydrate metabolism; DNA-binding;
KW   Nucleotide-binding; Transcription; Transcription regulation.
FT   CHAIN           1..902
FT                   /note="HTH-type transcriptional regulator MalT"
FT                   /id="PRO_1000085782"
FT   DOMAIN          832..897
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   DNA_BIND        856..875
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
SQ   SEQUENCE   902 AA;  103870 MW;  6FCD39F9410492FD CRC64;
     MWIPSKLTRP GRLHNAIVRP RVLDLLQQAP YYKLVLFRSP AGYGKTTMAA QWLSDKPNVG
     WYSIDDSDND GFRFVNYLLQ ALNKATNYNC SNAQKLAEKR QFSSLRSLFS EVFAEMADFQ
     HECYVVLDDY HLITNDEIHE SMRFFLKHMP DNLTVVVTSR AAPPLGTANL RVRDLMIEIG
     NEMLAFDTEE TTRFFNQRIA DGIDEDMANN LRTYVEGWPS ALQLIALQAQ HQNRTLAQTV
     ESVSQFNHAH LWDYLVEEVF DLLDQETRHF LMQVSVLDHF NDELVFALTQ REDALGMIES
     LNRFGLFIYP LEGEQNWFRF HNLFGEFLSH ERLARIPQQE KDLHRNAAVA WLKQKAPHQA
     IHHAQKSNDT DLIVEILNEF GWKMFNQGEL TTLESAINQL DKDLLFSHPK LSMLRAWLAQ
     SQHRYNQVGK LLAEAEEEHK KRNIEIDSGY QGQANALLAQ VAINSNQPEH ALELAELALS
     QLDPTVYRSR IVATSVVGEV NHVLGKLDRA LPMMQQTEKL ARQYQVYHQA LWAILQQSEI
     MIAQGYVQAA FELQDSGFRL IEEQQLQHVP LHEFLLRIRA QVLWCWNRLD EAEECAYKGL
     QILENHSPSK HLHSYSMLAR IAIGRGELDK AGKFIEHIQH LMKQSTYHVD WTANASLSLI
     LFWQARGNTE AIQEWLNTAV RPESACNHFQ QLQWRNIARA HINLGQYDEA REALDFLQSE
     AHRTNLVTDT NRNLVVEAIL AARQKDEEQA KTLLKEALVM TNQTGMVGNF LTDGATIGGL
     LEKLSLRHEL GDLERHRAQQ LMKDISSNQR SRSIHFDEDF IEKLVNHPNV PELVRTSPLT
     QREWQVLGLI YSGFSNEQIA QELDVAGTTI KTHIRNLYQK LNIANRKEAI VTAENLLQLM
     GY