MALT_VIBCH
ID MALT_VIBCH Reviewed; 902 AA.
AC Q9KNF3;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
DE AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
GN Name=malT {ECO:0000255|HAMAP-Rule:MF_01247}; OrderedLocusNames=VC_A0011;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Positively regulates the transcription of the maltose regulon
CC whose gene products are responsible for uptake and catabolism of malto-
CC oligosaccharides. Specifically binds to the promoter region of its
CC target genes, recognizing a short DNA motif called the MalT box.
CC {ECO:0000255|HAMAP-Rule:MF_01247}.
CC -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are both
CC required for DNA binding. {ECO:0000255|HAMAP-Rule:MF_01247}.
CC -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in the
CC presence of the positive effectors ATP and maltotriose.
CC {ECO:0000255|HAMAP-Rule:MF_01247}.
CC -!- SIMILARITY: Belongs to the MalT family. {ECO:0000255|HAMAP-
CC Rule:MF_01247}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF95925.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE003853; AAF95925.1; ALT_INIT; Genomic_DNA.
DR PIR; D82513; D82513.
DR RefSeq; NP_232412.1; NC_002506.1.
DR RefSeq; WP_000264940.1; NZ_LT906615.1.
DR AlphaFoldDB; Q9KNF3; -.
DR SMR; Q9KNF3; -.
DR STRING; 243277.VC_A0011; -.
DR DNASU; 2612296; -.
DR EnsemblBacteria; AAF95925; AAF95925; VC_A0011.
DR KEGG; vch:VC_A0011; -.
DR PATRIC; fig|243277.26.peg.2659; -.
DR eggNOG; COG2909; Bacteria.
DR HOGENOM; CLU_006325_3_0_6; -.
DR OMA; SDWVSNA; -.
DR Proteomes; UP000000584; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01247; HTH_type_MalT; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR041617; TPR_MalT.
DR InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF17874; TPR_MalT; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; Carbohydrate metabolism; DNA-binding;
KW Nucleotide-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..902
FT /note="HTH-type transcriptional regulator MalT"
FT /id="PRO_0000184169"
FT DOMAIN 832..897
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT DNA_BIND 856..875
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
SQ SEQUENCE 902 AA; 103589 MW; 721E794ADA05FD5F CRC64;
MWIPSKLTRP GRLHNAIVRP RVLDLLQHAT CYKLVLFRSP AGYGKTTMAA QWLADKPNLG
WYSIDDSDND PFRFMNYLLQ AINKATHNAC PNAQKLAEKR QFSSLHSLFS EVFAEMADYH
GECYVVLDDY HLIHDETIHE AMRFFLKHMP DNLTLVVTSR STPPLGTANL RVRDLMIEIG
NELLAFDTEE TTRFFNQRVS DGIDALTANH LRDYVEGWPS AMQLIALQAQ HQHRTLAQTI
ESVSHFNHAH LWDYLVEEVF DLLDDETRYF LMQCSVLDHF DDALVSSLTG RDDALAMIES
LNRFGLFISP LEGETNWYRF HNLFAEFLAH QRQARIPQQE QDLQRAAAKA WLEAAAPHQA
LRHAHLAQDT ELLASILSQY GWKMFNQGEL EVLEAAINQL SPPQLYREPK LCMLQAWLAQ
SQHRYNDVGA LLAKAAKEMK ALNVELSTKE QGEFNALRAQ VAINQNEPEK ALELAELALS
QLDHTTYRSR IVATSVVGEV NHVLGHLSRA LSMMQQTEKL ARQYQVYHQA LWALLQQSEI
LLAQGYVQAA YEVQDNAFKL IEEQQLHQVP LHEFLLRIRA QILWCWNRLD EAEQAAYKGL
SVLENHSQSK HLHCYSMLAR IAIGRGELDK AGRFIEQIQH LLKQSTYHVD WTANASLSLL
LYWQVKENST EIRQWLQSST RPDKACNHFS QLQWRNIARA QIQLGELSEA RHTLDFIQEQ
AQEYQLVTDT NRNLIVEALL AITEGDDLQA CHKLKQALRL TNQTGMIGNF LIDGSKIGHL
LEKLVHKGEL GDLERHRAHL LLKEISTTQR SRSIHFDEEF VEKLVNHPNI PELVRTSPLT
QREWQVLGLI YSGFSNEQIA HELDVAGTTI KTHIRNLYQK LNIANRKEAV QTAEQLLQLM
GY
