ID   MALT_VIBVY              Reviewed;         902 AA.
AC   Q7MG94;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
DE   AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000255|HAMAP-Rule:MF_01247};
GN   Name=malT {ECO:0000255|HAMAP-Rule:MF_01247}; OrderedLocusNames=VVA0076;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Positively regulates the transcription of the maltose regulon
CC       whose gene products are responsible for uptake and catabolism of malto-
CC       oligosaccharides. Specifically binds to the promoter region of its
CC       target genes, recognizing a short DNA motif called the MalT box.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are both
CC       required for DNA binding. {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in the
CC       presence of the positive effectors ATP and maltotriose.
CC       {ECO:0000255|HAMAP-Rule:MF_01247}.
CC   -!- SIMILARITY: Belongs to the MalT family. {ECO:0000255|HAMAP-
CC       Rule:MF_01247}.
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DR   EMBL; BA000038; BAC96101.1; -; Genomic_DNA.
DR   RefSeq; WP_011151506.1; NC_005140.1.
DR   AlphaFoldDB; Q7MG94; -.
DR   SMR; Q7MG94; -.
DR   STRING; 672.VV93_v1c30870; -.
DR   EnsemblBacteria; BAC96101; BAC96101; BAC96101.
DR   KEGG; vvy:VVA0076; -.
DR   PATRIC; fig|196600.6.peg.3297; -.
DR   eggNOG; COG2909; Bacteria.
DR   HOGENOM; CLU_006325_3_0_6; -.
DR   OMA; SDWVSNA; -.
DR   OrthoDB; 1377603at2; -.
DR   Proteomes; UP000002675; Chromosome II.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01247; HTH_type_MalT; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Carbohydrate metabolism; DNA-binding;
KW   Nucleotide-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..902
FT                   /note="HTH-type transcriptional regulator MalT"
FT                   /id="PRO_0000184172"
FT   DOMAIN          832..897
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   DNA_BIND        856..875
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01247"
SQ   SEQUENCE   902 AA;  103847 MW;  487D977F7A84AE39 CRC64;
     MWIPSKLTRP GRLHNAIVRP RVLELLQQAP YYKLVLFRSP AGYGKTTMAA QWLADKTNVG
     WYSIDDSDND GFRFINYLLQ ALNKATNGNC NNAQKLAEKR QFSSLRSLFS DVFAEMVDFH
     QECYVVLDDY HVINNEEVHE AMRFFLKHMP DNLTLVVTSR ANPPLGTANL RVRDLMIEIG
     NEMLAFDTEE TTRFFNQRVA DGIDEDTANN LRNYVEGWPS ALQLIALQAQ HQKRTLAQSA
     ESVSQFNHAH LWDYLVEEVF DLLDADTRKF LMQVSVLDHF NDELVYALTQ REDALGMIES
     LNRYGLFIYP LEGEQNWFRF HNLFGEFLSH ERQARIPQQE QELNRNAAIA WLKQKSPHQA
     IRHAQKAYDG ELVAEILNEF GWKMFNQGEL STLESAINLL EKDLLFSNPK LTMLRAWLAQ
     SQHRYNQVGT LLAEAENEHK KRNIDLDIQY QGQANALLAQ VAINSNDPEK ALELAELALS
     QLDSTVYRSR IVATSVVGEV NHVIGRLDRA LPMMQQTEKL ARQYQVYHQA LWAILQQSEI
     LIAQGYVQAA FELQDSAFRL IEEQQLQHVP LHEFLLRVRA QVLWCWNRLD EAEECAYKGL
     QILENHAPSK HLHSYSMLAR IAIGRGELDR AGKFIEHIQH LMKQSTYHVD WTANASLSLI
     LYWQAKGKLN AIQEWLNTAV RPENACNHFC QLQWRNIARA HINLGQYDQA RQALDFLQSE
     AEKANLVTDR NRNLIIEAIF AVHQKDENQA KVLLKEALQL TNQTGMVGNF LIDGATIGTL
     LEKLTNRHEL GDLERHRALQ LMKDISSNQR SRSVHFDEEF VEKLVTHPNV PELVRTSPLT
     QREWQVLGLI YSGFSNEQIA QELDVAGTTI KTHIRNLYQK LNIANRKEAV TTAENLLQLM
     GY