MAL_BOVIN
ID MAL_BOVIN Reviewed; 153 AA.
AC Q3ZBY0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Myelin and lymphocyte protein;
GN Name=MAL;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could be an important component in vesicular trafficking
CC cycling between the Golgi complex and the apical plasma membrane. Could
CC be involved in myelin biogenesis and/or myelin function (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: Lipoprotein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; BC103042; AAI03043.1; -; mRNA.
DR RefSeq; NP_001068896.1; NM_001075428.2.
DR AlphaFoldDB; Q3ZBY0; -.
DR STRING; 9913.ENSBTAP00000033149; -.
DR PaxDb; Q3ZBY0; -.
DR Ensembl; ENSBTAT00000033229; ENSBTAP00000033149; ENSBTAG00000034586.
DR GeneID; 510077; -.
DR KEGG; bta:510077; -.
DR CTD; 4118; -.
DR VEuPathDB; HostDB:ENSBTAG00000034586; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000154987; -.
DR InParanoid; Q3ZBY0; -.
DR OMA; FPDIFFI; -.
DR OrthoDB; 1518300at2759; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000034586; Expressed in anterior segment of eyeball and 96 other tissues.
DR ExpressionAtlas; Q3ZBY0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..153
FT /note="Myelin and lymphocyte protein"
FT /id="PRO_0000238631"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 153 AA; 16784 MW; 526E0E0192C4F83E CRC64;
MAPSAASGVS SLPSGFAVFT TFPDLLFIFE FVFGGLVWIL VSSSHVPIPL IQGWVMFASV
FCFVATTVLA FLYVIGAHGN RTSWITLDAA YHCVASLFYF GASVLEALAA IQLQDGFLYK
YYHENISAVV FSYVATLLYV VHAVFSLIRW KSS
