MAL_CANLF
ID MAL_CANLF Reviewed; 153 AA.
AC Q28296;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Myelin and lymphocyte protein;
DE AltName: Full=T-lymphocyte maturation-associated protein;
DE AltName: Full=VIP17 proteolipid;
GN Name=MAL;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Cocker spaniel; TISSUE=Kidney;
RX PubMed=8549777; DOI=10.1016/0014-5793(95)01396-2;
RA Zacchetti D., Peraenen J., Murata M., Fiedler K., Simons K.;
RT "VIP17/MAL, a proteolipid in apical transport vesicles.";
RL FEBS Lett. 377:465-469(1995).
CC -!- FUNCTION: Could be an important component in vesicular trafficking
CC cycling between the Golgi complex and the apical plasma membrane. Could
CC be involved in myelin biogenesis and/or myelin function.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Lipoprotein.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; X92505; CAA63261.1; -; mRNA.
DR PIR; S68406; S68406.
DR RefSeq; NP_001003253.1; NM_001003253.1.
DR AlphaFoldDB; Q28296; -.
DR STRING; 9615.ENSCAFP00000050507; -.
DR TCDB; 1.A.64.2.1; the plasmolipin (plasmolipin) family.
DR PaxDb; Q28296; -.
DR GeneID; 403933; -.
DR KEGG; cfa:403933; -.
DR CTD; 4118; -.
DR eggNOG; KOG4788; Eukaryota.
DR InParanoid; Q28296; -.
DR OrthoDB; 1518300at2759; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IDA:UniProtKB.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..153
FT /note="Myelin and lymphocyte protein"
FT /id="PRO_0000156804"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 153 AA; 16624 MW; 3E521B023B9CBD9B CRC64;
MAPAAASGGS SLPSGFSVFT TFPDLLFIFE FIFGGLVWIL IASSLVPIPL VQGWVMFVSV
FCFMATTALL VLYIIGAHGG ENSWVTLDAA YHCIAALFYL SASVLEALAT IGMQEGYTYK
QYHENISAVV FSYVATLLYV VHAVFSLIRW KSS
