MAL_HUMAN
ID MAL_HUMAN Reviewed; 153 AA.
AC P21145; Q6FH77;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Myelin and lymphocyte protein;
DE AltName: Full=T-lymphocyte maturation-associated protein;
GN Name=MAL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3494249; DOI=10.1073/pnas.84.7.1997;
RA Alonso M.A., Weissman S.M.;
RT "cDNA cloning and sequence of MAL, a hydrophobic protein associated with
RT human T-cell differentiation.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=8088843; DOI=10.1006/geno.1994.1294;
RA Rancano C., Rubio T., Alonso M.A.;
RT "Alternative splicing of human T-cell-specific MAL mRNA and its correlation
RT with the exon/intron organization of the gene.";
RL Genomics 21:447-450(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lymphocyte, and Placenta;
RX PubMed=8132541; DOI=10.1016/s0021-9258(17)37174-0;
RA Rancano C., Rubio T., Correas I., Alonso M.A.;
RT "Genomic structure and subcellular localization of MAL, a human T-cell-
RT specific proteolipid protein.";
RL J. Biol. Chem. 269:8159-8164(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could be an important component in vesicular trafficking
CC cycling between the Golgi complex and the apical plasma membrane. Could
CC be involved in myelin biogenesis and/or myelin function.
CC -!- INTERACTION:
CC P21145; Q16671: AMHR2; NbExp=3; IntAct=EBI-3932027, EBI-6423788;
CC P21145; Q13520: AQP6; NbExp=3; IntAct=EBI-3932027, EBI-13059134;
CC P21145; Q9BXK5: BCL2L13; NbExp=5; IntAct=EBI-3932027, EBI-747430;
CC P21145; Q06187: BTK; NbExp=5; IntAct=EBI-3932027, EBI-624835;
CC P21145; Q7KYR7-4: BTN2A1; NbExp=3; IntAct=EBI-3932027, EBI-17841208;
CC P21145; Q9BXU9: CALN1; NbExp=3; IntAct=EBI-3932027, EBI-12187137;
CC P21145; Q6UXG3: CD300LG; NbExp=3; IntAct=EBI-3932027, EBI-10254587;
CC P21145; P09693: CD3G; NbExp=3; IntAct=EBI-3932027, EBI-3862428;
CC P21145; P25942: CD40; NbExp=3; IntAct=EBI-3932027, EBI-525714;
CC P21145; P19397: CD53; NbExp=3; IntAct=EBI-3932027, EBI-6657396;
CC P21145; Q07108: CD69; NbExp=3; IntAct=EBI-3932027, EBI-2836595;
CC P21145; O95500: CLDN14; NbExp=3; IntAct=EBI-3932027, EBI-11742599;
CC P21145; P56880: CLDN20; NbExp=3; IntAct=EBI-3932027, EBI-23801559;
CC P21145; O95471: CLDN7; NbExp=3; IntAct=EBI-3932027, EBI-740744;
CC P21145; O95484: CLDN9; NbExp=3; IntAct=EBI-3932027, EBI-18341636;
CC P21145; Q8WTT0: CLEC4C; NbExp=4; IntAct=EBI-3932027, EBI-12913226;
CC P21145; Q9BQT9: CLSTN3; NbExp=3; IntAct=EBI-3932027, EBI-11291074;
CC P21145; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-3932027, EBI-18013275;
CC P21145; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-3932027, EBI-6942903;
CC P21145; P78310: CXADR; NbExp=3; IntAct=EBI-3932027, EBI-747931;
CC P21145; Q9Y4D2: DAGLA; NbExp=3; IntAct=EBI-3932027, EBI-12808806;
CC P21145; Q92838: EDA; NbExp=7; IntAct=EBI-3932027, EBI-529425;
CC P21145; P54849: EMP1; NbExp=3; IntAct=EBI-3932027, EBI-4319440;
CC P21145; P22794: EVI2A; NbExp=3; IntAct=EBI-3932027, EBI-2870359;
CC P21145; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-3932027, EBI-18304435;
CC P21145; Q96LA5-2: FCRL2; NbExp=3; IntAct=EBI-3932027, EBI-17263163;
CC P21145; Q8N539: FIBCD1; NbExp=6; IntAct=EBI-3932027, EBI-10200808;
CC P21145; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-3932027, EBI-12142257;
CC P21145; P48165: GJA8; NbExp=3; IntAct=EBI-3932027, EBI-17458373;
CC P21145; P08034: GJB1; NbExp=3; IntAct=EBI-3932027, EBI-17565645;
CC P21145; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-3932027, EBI-13345167;
CC P21145; Q96CP6: GRAMD1A; NbExp=3; IntAct=EBI-3932027, EBI-1384139;
CC P21145; Q6UXU4-2: GSG1L; NbExp=3; IntAct=EBI-3932027, EBI-18632127;
CC P21145; P31937: HIBADH; NbExp=3; IntAct=EBI-3932027, EBI-11427100;
CC P21145; Q13651: IL10RA; NbExp=3; IntAct=EBI-3932027, EBI-1031656;
CC P21145; Q6UXL0: IL20RB; NbExp=3; IntAct=EBI-3932027, EBI-14022792;
CC P21145; Q86YT9-2: JAML; NbExp=3; IntAct=EBI-3932027, EBI-17244059;
CC P21145; Q09470: KCNA1; NbExp=3; IntAct=EBI-3932027, EBI-8286599;
CC P21145; Q16322: KCNA10; NbExp=3; IntAct=EBI-3932027, EBI-12265328;
CC P21145; Q86W47: KCNMB4; NbExp=3; IntAct=EBI-3932027, EBI-19112227;
CC P21145; P26715: KLRC1; NbExp=6; IntAct=EBI-3932027, EBI-9018187;
CC P21145; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-3932027, EBI-10173166;
CC P21145; Q9H0V9: LMAN2L; NbExp=3; IntAct=EBI-3932027, EBI-9091707;
CC P21145; Q8N386: LRRC25; NbExp=3; IntAct=EBI-3932027, EBI-11304917;
CC P21145; Q9HBL6: LRTM1; NbExp=3; IntAct=EBI-3932027, EBI-12825005;
CC P21145; Q8N8F7: LSMEM1; NbExp=3; IntAct=EBI-3932027, EBI-10200825;
CC P21145; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-3932027, EBI-12820341;
CC P21145; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-3932027, EBI-10247000;
CC P21145; Q8IVV8: NKAIN4; NbExp=3; IntAct=EBI-3932027, EBI-17791123;
CC P21145; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-3932027, EBI-748927;
CC P21145; P35372-10: OPRM1; NbExp=3; IntAct=EBI-3932027, EBI-12807478;
CC P21145; Q96FX8: PERP; NbExp=3; IntAct=EBI-3932027, EBI-17183069;
CC P21145; O15496: PLA2G10; NbExp=3; IntAct=EBI-3932027, EBI-726466;
CC P21145; Q99946-2: PRRT1; NbExp=3; IntAct=EBI-3932027, EBI-12211089;
CC P21145; Q16849-3: PTPRN; NbExp=3; IntAct=EBI-3932027, EBI-10200782;
CC P21145; O60894: RAMP1; NbExp=3; IntAct=EBI-3932027, EBI-962893;
CC P21145; P31431: SDC4; NbExp=3; IntAct=EBI-3932027, EBI-3913237;
CC P21145; Q16585: SGCB; NbExp=3; IntAct=EBI-3932027, EBI-5663627;
CC P21145; A0PJX4: SHISA3; NbExp=3; IntAct=EBI-3932027, EBI-10171518;
CC P21145; Q96DD7: SHISA4; NbExp=3; IntAct=EBI-3932027, EBI-18035902;
CC P21145; Q14973: SLC10A1; NbExp=3; IntAct=EBI-3932027, EBI-3923031;
CC P21145; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-3932027, EBI-17295964;
CC P21145; Q9BZL3: SMIM3; NbExp=6; IntAct=EBI-3932027, EBI-741850;
CC P21145; O43278-2: SPINT1; NbExp=3; IntAct=EBI-3932027, EBI-12078338;
CC P21145; Q16623: STX1A; NbExp=4; IntAct=EBI-3932027, EBI-712466;
CC P21145; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-3932027, EBI-726331;
CC P21145; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-3932027, EBI-19027521;
CC P21145; Q495A1: TIGIT; NbExp=3; IntAct=EBI-3932027, EBI-4314807;
CC P21145; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-3932027, EBI-13351685;
CC P21145; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3932027, EBI-2821497;
CC P21145; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-3932027, EBI-10276729;
CC P21145; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-3932027, EBI-13301303;
CC P21145; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-3932027, EBI-10314986;
CC P21145; Q9NV96-2: TMEM30A; NbExp=3; IntAct=EBI-3932027, EBI-12921610;
CC P21145; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-3932027, EBI-18178701;
CC P21145; O43557: TNFSF14; NbExp=5; IntAct=EBI-3932027, EBI-524131;
CC P21145; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-3932027, EBI-12195249;
CC P21145; Q93009: USP7; NbExp=3; IntAct=EBI-3932027, EBI-302474;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=A;
CC IsoId=P21145-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P21145-2; Sequence=VSP_003164;
CC Name=C;
CC IsoId=P21145-3; Sequence=VSP_003163;
CC Name=D;
CC IsoId=P21145-4; Sequence=VSP_003162;
CC -!- DEVELOPMENTAL STAGE: Expressed in the intermediate and late stages of
CC T-cell differentiation.
CC -!- PTM: Lipoprotein.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/MALID46222ch2q11.html";
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DR EMBL; M15800; AAA36196.1; -; mRNA.
DR EMBL; X76678; CAA54100.1; -; mRNA.
DR EMBL; X76679; CAA54101.1; -; mRNA.
DR EMBL; X76680; CAA54102.1; -; mRNA.
DR EMBL; X76681; CAA54103.1; -; mRNA.
DR EMBL; X76220; CAA53809.1; -; Genomic_DNA.
DR EMBL; X76221; CAA53809.1; JOINED; Genomic_DNA.
DR EMBL; X76222; CAA53809.1; JOINED; Genomic_DNA.
DR EMBL; X76223; CAA53809.1; JOINED; Genomic_DNA.
DR EMBL; AK311844; BAG34786.1; -; mRNA.
DR EMBL; CR541879; CAG46677.1; -; mRNA.
DR EMBL; AC103563; AAY24121.1; -; Genomic_DNA.
DR EMBL; CH471219; EAX10705.1; -; Genomic_DNA.
DR EMBL; BC000458; AAH00458.1; -; mRNA.
DR EMBL; BC003006; AAH03006.1; -; mRNA.
DR CCDS; CCDS2006.1; -. [P21145-1]
DR CCDS; CCDS2007.1; -. [P21145-2]
DR CCDS; CCDS2008.1; -. [P21145-3]
DR CCDS; CCDS2009.1; -. [P21145-4]
DR PIR; A29472; A29472.
DR RefSeq; NP_002362.1; NM_002371.3. [P21145-1]
DR RefSeq; NP_071883.1; NM_022438.2. [P21145-2]
DR RefSeq; NP_071884.1; NM_022439.2. [P21145-3]
DR RefSeq; NP_071885.1; NM_022440.2. [P21145-4]
DR AlphaFoldDB; P21145; -.
DR BioGRID; 110292; 81.
DR IntAct; P21145; 86.
DR MINT; P21145; -.
DR STRING; 9606.ENSP00000310880; -.
DR TCDB; 1.A.64.2.2; the plasmolipin (plasmolipin) family.
DR BioMuta; MAL; -.
DR DMDM; 126719; -.
DR PaxDb; P21145; -.
DR PeptideAtlas; P21145; -.
DR PRIDE; P21145; -.
DR ProteomicsDB; 53849; -. [P21145-1]
DR ProteomicsDB; 53851; -. [P21145-3]
DR Antibodypedia; 32290; 235 antibodies from 30 providers.
DR DNASU; 4118; -.
DR Ensembl; ENST00000309988.9; ENSP00000310880.4; ENSG00000172005.11. [P21145-1]
DR Ensembl; ENST00000349807.3; ENSP00000322860.3; ENSG00000172005.11. [P21145-4]
DR Ensembl; ENST00000353004.7; ENSP00000306568.4; ENSG00000172005.11. [P21145-2]
DR Ensembl; ENST00000354078.7; ENSP00000304924.3; ENSG00000172005.11. [P21145-3]
DR GeneID; 4118; -.
DR KEGG; hsa:4118; -.
DR MANE-Select; ENST00000309988.9; ENSP00000310880.4; NM_002371.4; NP_002362.1.
DR UCSC; uc002stx.3; human. [P21145-1]
DR CTD; 4118; -.
DR DisGeNET; 4118; -.
DR GeneCards; MAL; -.
DR HGNC; HGNC:6817; MAL.
DR HPA; ENSG00000172005; Tissue enhanced (esophagus, vagina).
DR MalaCards; MAL; -.
DR MIM; 188860; gene.
DR neXtProt; NX_P21145; -.
DR OpenTargets; ENSG00000172005; -.
DR PharmGKB; PA30565; -.
DR VEuPathDB; HostDB:ENSG00000172005; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000154987; -.
DR HOGENOM; CLU_112950_0_0_1; -.
DR InParanoid; P21145; -.
DR OMA; FPDIFFI; -.
DR PhylomeDB; P21145; -.
DR TreeFam; TF316174; -.
DR PathwayCommons; P21145; -.
DR SignaLink; P21145; -.
DR BioGRID-ORCS; 4118; 18 hits in 1074 CRISPR screens.
DR ChiTaRS; MAL; human.
DR GeneWiki; MAL_(gene); -.
DR GenomeRNAi; 4118; -.
DR Pharos; P21145; Tbio.
DR PRO; PR:P21145; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P21145; protein.
DR Bgee; ENSG00000172005; Expressed in esophagus squamous epithelium and 178 other tissues.
DR ExpressionAtlas; P21145; baseline and differential.
DR Genevisible; P21145; HS.
DR GO; GO:0016324; C:apical plasma membrane; TAS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:Ensembl.
DR GO; GO:0120003; C:hinge region between urothelial plaques of apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:UniProtKB.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0008289; F:lipid binding; TAS:UniProtKB.
DR GO; GO:0016505; F:peptidase activator activity involved in apoptotic process; NAS:UniProtKB.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IDA:UniProtKB.
DR GO; GO:0045176; P:apical protein localization; TAS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; TAS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; TAS:UniProtKB.
DR GO; GO:0022010; P:central nervous system myelination; IEA:Ensembl.
DR GO; GO:0001766; P:membrane raft polarization; TAS:UniProtKB.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0098737; P:protein insertion into plasma membrane; IEA:Ensembl.
DR GO; GO:0002175; P:protein localization to paranode region of axon; IEA:Ensembl.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..153
FT /note="Myelin and lymphocyte protein"
FT /id="PRO_0000156805"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 32..129
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_003162"
FT VAR_SEQ 32..87
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_003163"
FT VAR_SEQ 88..129
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_003164"
SQ SEQUENCE 153 AA; 16714 MW; F821FC1C0ADBE775 CRC64;
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV
FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL SASVLEALAT ITMQDGFTYR
HYHENIAAVV FSYIATLLYV VHAVFSLIRW KSS
