MAL_RAT
ID MAL_RAT Reviewed; 153 AA.
AC Q64349;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Myelin and lymphocyte protein;
DE AltName: Full=17 kDa myelin vesicular protein;
DE Short=MVP17;
DE AltName: Full=NS 3;
DE AltName: Full=T-lymphocyte maturation-associated protein;
GN Name=Mal; Synonyms=Mvp17;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=8583510; DOI=10.1002/jnr.490420316;
RA Kim T., Fiedler K., Madison D.L., Krueger W.H., Pfeiffer S.E.;
RT "Cloning and characterization of MVP17: a developmentally regulated myelin
RT protein in oligodendrocytes.";
RL J. Neurosci. Res. 42:413-422(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Lewis; TISSUE=Spinal cord;
RX PubMed=7643216; DOI=10.1523/jneurosci.15-08-05753.1995;
RA Schaeren-Wiemers N., Valenzuela D.M., Frank M., Schwab M.E.;
RT "Characterization of a rat gene, rMAL, encoding a protein with four
RT hydrophobic domains in central and peripheral myelin.";
RL J. Neurosci. 15:5753-5764(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could be an important component in vesicular trafficking
CC cycling between the Golgi complex and the apical plasma membrane. Could
CC be involved in myelin biogenesis and/or myelin function.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in white and gray matter
CC oligodendrocytes in the CNS and in myelinating Schwann cells in
CC peripheral nerves. Higher levels are found in the PNS than in the CNS
CC or spinal cord, in the gray matter than in the white. Weak expression
CC also found in spleen and kidney.
CC -!- DEVELOPMENTAL STAGE: Detected just before birth in Schwann cells and
CC after birth in oligodendrocytes of brainstem and spinal cord.
CC -!- INDUCTION: Up-regulated during myelination.
CC -!- PTM: Lipoprotein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; U31367; AAC52366.1; -; mRNA.
DR EMBL; X82557; CAA57903.1; -; mRNA.
DR EMBL; BC085755; AAH85755.1; -; mRNA.
DR RefSeq; NP_036930.1; NM_012798.1.
DR AlphaFoldDB; Q64349; -.
DR DIP; DIP-46222N; -.
DR IntAct; Q64349; 1.
DR STRING; 10116.ENSRNOP00000020870; -.
DR PaxDb; Q64349; -.
DR Ensembl; ENSRNOT00000020870; ENSRNOP00000020870; ENSRNOG00000015445.
DR GeneID; 25263; -.
DR KEGG; rno:25263; -.
DR UCSC; RGD:3037; rat.
DR CTD; 4118; -.
DR RGD; 3037; Mal.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000154987; -.
DR HOGENOM; CLU_112950_0_0_1; -.
DR InParanoid; Q64349; -.
DR OMA; FPDIFFI; -.
DR OrthoDB; 1518300at2759; -.
DR PhylomeDB; Q64349; -.
DR TreeFam; TF316174; -.
DR PRO; PR:Q64349; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000015445; Expressed in stomach and 19 other tissues.
DR Genevisible; Q64349; RN.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0019898; C:extrinsic component of membrane; IDA:RGD.
DR GO; GO:0120003; C:hinge region between urothelial plaques of apical plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:RGD.
DR GO; GO:0044853; C:plasma membrane raft; ISO:RGD.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IDA:RGD.
DR GO; GO:0022010; P:central nervous system myelination; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; TAS:RGD.
DR GO; GO:0042552; P:myelination; IDA:RGD.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:RGD.
DR GO; GO:0098737; P:protein insertion into plasma membrane; ISO:RGD.
DR GO; GO:0002175; P:protein localization to paranode region of axon; ISO:RGD.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..153
FT /note="Myelin and lymphocyte protein"
FT /id="PRO_0000156807"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 153 AA; 16758 MW; C98996D2C3612494 CRC64;
MAPAAASGGS TLPSGFSVFV TFPDLLFIFE FIFGGLVWIL IASSLVPMPL VQGWVMFVSV
FCFLATTSLM VMYIIGTHGG ETSWITLDAA YHCVAALFYL SASVLEALAT ITMFDGFTYR
HYHENIAAVV FAYVATLLYV IHAVFSLIRW KSS
