ID   MAM2_SCHPO              Reviewed;         348 AA.
AC   Q00619;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Pheromone P-factor receptor;
GN   Name=mam2; ORFNames=SPAC11H11.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 38365 / 975;
RX   PubMed=1657593; DOI=10.1002/j.1460-2075.1991.tb04943.x;
RA   Kitamura K., Shimoda C.;
RT   "The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone
RT   receptor which has a significant homology with the Saccharomyces cerevisiae
RT   Ste2 protein.";
RL   EMBO J. 10:3743-3751(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Receptor for the peptide pheromone P-factor, a mating factor
CC       of S.pombe. Pheromone signaling is essential for initiation of meiosis
CC       in S.pombe; P-factor signaling alone may be sufficient.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 4 family.
CC       {ECO:0000305}.
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DR   EMBL; X61672; CAA43846.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB59800.1; -; Genomic_DNA.
DR   PIR; S18521; S18521.
DR   RefSeq; NP_594722.1; NM_001020150.2.
DR   AlphaFoldDB; Q00619; -.
DR   SMR; Q00619; -.
DR   BioGRID; 278103; 4.
DR   STRING; 4896.SPAC11H11.04.1; -.
DR   PaxDb; Q00619; -.
DR   EnsemblFungi; SPAC11H11.04.1; SPAC11H11.04.1:pep; SPAC11H11.04.
DR   GeneID; 2541606; -.
DR   KEGG; spo:SPAC11H11.04; -.
DR   PomBase; SPAC11H11.04; mam2.
DR   VEuPathDB; FungiDB:SPAC11H11.04; -.
DR   eggNOG; ENOG502QTV4; Eukaryota.
DR   HOGENOM; CLU_035056_1_0_1; -.
DR   InParanoid; Q00619; -.
DR   OMA; FIMGCQT; -.
DR   PhylomeDB; Q00619; -.
DR   PRO; PR:Q00619; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005938; C:cell cortex; IDA:PomBase.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0051286; C:cell tip; HDA:PomBase.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR   GO; GO:0038038; C:G protein-coupled receptor homodimeric complex; IDA:PomBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:PomBase.
DR   GO; GO:0070250; C:mating projection membrane; IDA:PomBase.
DR   GO; GO:0031520; C:plasma membrane of cell tip; IDA:PomBase.
DR   GO; GO:0004932; F:mating-type factor pheromone receptor activity; IBA:GO_Central.
DR   GO; GO:0036320; F:mating-type P-factor pheromone receptor activity; IDA:PomBase.
DR   GO; GO:0005550; F:pheromone binding; IDA:PomBase.
DR   GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IBA:GO_Central.
DR   GO; GO:0031139; P:positive regulation of conjugation with cellular fusion; IMP:PomBase.
DR   GO; GO:0062038; P:positive regulation of pheromone response MAPK cascade; IMP:PomBase.
DR   Gene3D; 1.10.287.920; -; 1.
DR   InterPro; IPR000366; GPCR_STE2.
DR   InterPro; IPR027458; STE2_TM1-TM2_sf.
DR   PANTHER; PTHR28009; PTHR28009; 1.
DR   Pfam; PF02116; STE2; 1.
DR   PRINTS; PR00250; GPCRSTE2.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Membrane; Pheromone response; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Pheromone P-factor receptor"
FT                   /id="PRO_0000195074"
FT   TRANSMEM        46..69
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..103
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..180
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..267
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..301
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  39286 MW;  3235DE5E3E513EB0 CRC64;
     MRQPWWKDFT IPDASAIIHQ NITIVSIVGE IEVPVSTIDA YERDRLLTGM TLSAQLALGV
     LTILMVCLLS SSEKRKHPVF VFNSASIVAM CLRAILNIVT ICSNSYSILV NYGFILNMVH
     MYVHVFNILI LLLAPVIIFT AEMSMMIQVR IICAHDRKTQ RIMTVISACL TVLVLAFWIT
     NMCQQIQYLL WLTPLSSKTI VGYSWPYFIA KILFAFSIIF HSGVFSYKLF RAILIRKKIG
     QFPFGPMQCI LVISCQCLIV PATFTIIDSF IHTYDGFSSM TQCLLIISLP LSSLWASSTA
     LKLQSMKTSS AQGETTEVSI RVDRTFDIKH TPSDDYSISD ESETKKWT