MAML2_BOVIN
ID MAML2_BOVIN Reviewed; 1128 AA.
AC A5D7F6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Mastermind-like protein 2;
DE Short=Mam-2;
GN Name=MAML2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has
CC been shown to amplify NOTCH-induced transcription of HES1. Potentiates
CC activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts through its N-terminal region with the ankyrin
CC repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4.
CC Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Nuclear, in a
CC punctate manner. {ECO:0000250}.
CC -!- DOMAIN: The C-terminal domain is required for transcriptional
CC activation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mastermind family. {ECO:0000305}.
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DR EMBL; BC140537; AAI40538.1; -; mRNA.
DR RefSeq; NP_001091519.1; NM_001098050.1.
DR AlphaFoldDB; A5D7F6; -.
DR SMR; A5D7F6; -.
DR STRING; 9913.ENSBTAP00000051992; -.
DR PaxDb; A5D7F6; -.
DR PRIDE; A5D7F6; -.
DR GeneID; 521194; -.
DR KEGG; bta:521194; -.
DR CTD; 84441; -.
DR eggNOG; ENOG502QVWD; Eukaryota.
DR InParanoid; A5D7F6; -.
DR OrthoDB; 296895at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0007221; P:positive regulation of transcription of Notch receptor target; IBA:GO_Central.
DR Gene3D; 6.10.250.970; -; 1.
DR InterPro; IPR046369; MAML1-3.
DR InterPro; IPR046370; MAML_N_sf.
DR InterPro; IPR019082; Mastermind-like_N.
DR PANTHER; PTHR15692; PTHR15692; 1.
DR Pfam; PF09596; MamL-1; 1.
DR SMART; SM01275; MamL-1; 1.
PE 2: Evidence at transcript level;
KW Activator; Notch signaling pathway; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1128
FT /note="Mastermind-like protein 2"
FT /id="PRO_0000317429"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..128
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZL2"
SQ SEQUENCE 1128 AA; 120886 MW; DCF9B3BAE7841566 CRC64;
MGDTAPPQAP TGGLGGAPGA GLLGGGSVTP RVHSAIVERL RARIAVCRQH HLSCEGRYER
GRAESSDRER ESTLQLLSLV QHGQGARKAG KHTKATASTA TATAPPPAPA APPTASQTAA
PAAPAPPPDY HHHHQQHLRS SSSSGGSGGI DGEQQQQPPA STPGDQRNSA LIALQGSLKR
KQIVNLSPAN SKRPNGFVDN SFLDIKRIRV GENLAAGPGG LPVNNGQSQM MSGTLPMSQV
PLRKTAALPP PPTHSPGNGL FNMGLKEVKK EPGETLSCSK HVDGQVTQEN IFSNRYGDDP
GEQLMDPELQ ELFNELTNIS VPPMSDLELE NMINATIKQD DPFNIDLGQQ SQRSTPRPSL
PLEKTVIKSE YSPGLTQGPS GSPQLRPSSA GPAFSMASSG LSASSPIPSV PQSQAQPPPA
TGAARALPSW QEVSHAQQLK QIAANRQQHV RMHQQQQQHQ PTSWPALPSS AGPSPGPFGQ
EKIPSPSFGQ QPFSPQSTPM PGVTGGSNQS KVMANYLFKA SPSAQGGPLD VLLQPKPQDL
SRSFLNNPHP AMEPRHGSTK PLFHFNSDQA NQQMPSVLPS QSKPSLLHYT QQQPQQSSIT
VQPQQQQQQP QQQQQPQQQQ QPQPQQQQQQ QPQAQQPAAQ PTQPLSNQPL LRAPLPLQQK
ILLQKIQNQP ITGLGYQVSQ QHRQDQHSVV GQNAGPSPSP NPCSNPNTGS GYMNSQQSLL
NQQLMGKKQT LQRQIMEQKQ QLLLQQQMLA DAEKIAPQDQ INRHLTRPPP DYKDQRRNVG
NMQPTAQYSG GSSTVSLNSN QALANPVSTH TILTPNSSLM STSHGTRMPS LPTAVQNIGI
YGNLPCSQPS TYSVTSGMNQ LTQPRNPNQL IANQNNPLMP RPPTLGPSNN NNNNVATFGA
GSVGNSQQLR PNLTHSMASM PAQRTSNVMI TSNTATPNWA SQEATAKQQE ALKSAGVRFP
TGTTTAYAPN QSLQQAVGSQ QFSQRAVAPS NQLTPAVQMR PMNQMSQTLN GQNMGPLRSL
NLRPNQLSTQ LLPTMNQAGT GLSQSRTVSQ PPSLAAGGFP SPNQSSRAFQ GTDHGNDLAF
DFLNQQTDNM GPALNSDADF IDSLLKTEPG NDDWMKDINL DEILGNNS
