MAM_DROME
ID MAM_DROME Reviewed; 1594 AA.
AC P21519; B5RJ79; Q0E983; Q494M5; Q7KR72; Q8SZU8; Q9V6W7; Q9V6W8;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Neurogenic protein mastermind;
GN Name=mam; ORFNames=CG8118;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=1701150; DOI=10.1101/gad.4.10.1688;
RA Smoller D., Friedel C., Schmid A., Bettler D., Lam L., Yedvobnick B.;
RT "The Drosophila neurogenic locus mastermind encodes a nuclear protein
RT unusually rich in amino acid homopolymers.";
RL Genes Dev. 4:1688-1700(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C).
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Booth B., Chavez C., Frise E., George R.A.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16508010; DOI=10.1128/mcb.26.6.2347-2359.2006;
RA Gause M., Eissenberg J.C., Macrae A.F., Dorsett M., Misulovin Z.,
RA Dorsett D.;
RT "Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60
RT complexes, has multiple roles in Notch signaling during wing development.";
RL Mol. Cell. Biol. 26:2347-2359(2006).
CC -!- FUNCTION: May have a regulatory function possibly in association with
CC the Notch gene product. {ECO:0000269|PubMed:16508010}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1701150}. Chromosome
CC {ECO:0000269|PubMed:16508010}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A; Synonyms=B;
CC IsoId=P21519-1; Sequence=Displayed;
CC Name=C;
CC IsoId=P21519-2; Sequence=VSP_014690, VSP_014691, VSP_014692,
CC VSP_014693;
CC -!- DEVELOPMENTAL STAGE: During early neurogenesis, expression is
CC ubiquitous. During later stages, expression concentrates at the central
CC nervous system. {ECO:0000269|PubMed:1701150}.
CC -!- DOMAIN: The protein has many AA homomeric domains: 21 poly-Gln runs
CC (from 5 to 16 AA in length), 4 poly-Gly (6 to 10 AA), 3 poly-Asn (3 X 5
CC AA), 1 poly-Ala (10 AA) and 1 poly-Thr (5 AA) runs.
CC -!- SIMILARITY: Belongs to the mastermind family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL47970.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X54251; CAA38152.1; -; mRNA.
DR EMBL; AE013599; AAF58299.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF58300.2; -; Genomic_DNA.
DR EMBL; AE013599; AAS64855.1; -; Genomic_DNA.
DR EMBL; AY070499; AAL47970.1; ALT_FRAME; mRNA.
DR EMBL; BT023751; AAZ41759.1; -; mRNA.
DR EMBL; BT044353; ACH92418.1; -; mRNA.
DR PIR; A36391; A33106.
DR RefSeq; NP_001286401.1; NM_001299472.1. [P21519-1]
DR RefSeq; NP_525115.1; NM_080376.2. [P21519-1]
DR RefSeq; NP_725354.1; NM_166030.2. [P21519-1]
DR RefSeq; NP_995831.1; NM_206109.2. [P21519-2]
DR AlphaFoldDB; P21519; -.
DR BioGRID; 62308; 70.
DR DIP; DIP-62093N; -.
DR IntAct; P21519; 3.
DR STRING; 7227.FBpp0086722; -.
DR PaxDb; P21519; -.
DR DNASU; 36555; -.
DR EnsemblMetazoa; FBtr0087596; FBpp0086722; FBgn0002643. [P21519-1]
DR EnsemblMetazoa; FBtr0087597; FBpp0086723; FBgn0002643. [P21519-1]
DR EnsemblMetazoa; FBtr0087598; FBpp0086724; FBgn0002643. [P21519-2]
DR EnsemblMetazoa; FBtr0339956; FBpp0308978; FBgn0002643. [P21519-1]
DR GeneID; 36555; -.
DR KEGG; dme:Dmel_CG8118; -.
DR CTD; 36555; -.
DR FlyBase; FBgn0002643; mam.
DR VEuPathDB; VectorBase:FBgn0002643; -.
DR eggNOG; ENOG502RYPM; Eukaryota.
DR HOGENOM; CLU_005423_0_0_1; -.
DR InParanoid; P21519; -.
DR OMA; NGGMMAG; -.
DR PhylomeDB; P21519; -.
DR SignaLink; P21519; -.
DR BioGRID-ORCS; 36555; 0 hits in 1 CRISPR screen.
DR ChiTaRS; mam; fly.
DR GenomeRNAi; 36555; -.
DR PRO; PR:P21519; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0002643; Expressed in saliva-secreting gland and 39 other tissues.
DR ExpressionAtlas; P21519; baseline and differential.
DR Genevisible; P21519; DM.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:1990433; C:CSL-Notch-Mastermind transcription factor complex; IDA:FlyBase.
DR GO; GO:0016607; C:nuclear speck; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005700; C:polytene chromosome; IDA:FlyBase.
DR GO; GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:FlyBase.
DR GO; GO:0007475; P:apposition of dorsal and ventral imaginal disc-derived wing surfaces; IMP:FlyBase.
DR GO; GO:0008356; P:asymmetric cell division; IMP:FlyBase.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase.
DR GO; GO:0003007; P:heart morphogenesis; IMP:FlyBase.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0046331; P:lateral inhibition; IMP:FlyBase.
DR GO; GO:0007500; P:mesodermal cell fate determination; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; IMP:FlyBase.
DR GO; GO:0048664; P:neuron fate determination; IGI:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IDA:FlyBase.
DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:FlyBase.
DR GO; GO:0007418; P:ventral midline development; IMP:FlyBase.
DR Gene3D; 6.10.250.970; -; 1.
DR InterPro; IPR046370; MAML_N_sf.
DR InterPro; IPR019082; Mastermind-like_N.
DR Pfam; PF09596; MamL-1; 1.
DR SMART; SM01275; MamL-1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chromosome; Developmental protein; Differentiation;
KW Neurogenesis; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1594
FT /note="Neurogenic protein mastermind"
FT /id="PRO_0000129497"
FT REPEAT 986..987
FT /note="1-1"
FT REPEAT 988..989
FT /note="2-1"
FT REPEAT 990..991
FT /note="3-1"
FT REPEAT 992..993
FT /note="4-1"
FT REPEAT 994..995
FT /note="5-1"
FT REPEAT 1091..1092
FT /note="1-2"
FT REPEAT 1093..1094
FT /note="2-2"
FT REPEAT 1095..1096
FT /note="3-2"
FT REPEAT 1097..1098
FT /note="4-2"
FT REPEAT 1099..1100
FT /note="5-2"
FT REPEAT 1101..1102
FT /note="6-2"
FT REPEAT 1103..1104
FT /note="7-2"
FT REPEAT 1105..1106
FT /note="8-2"
FT REPEAT 1236..1237
FT /note="1-3"
FT REPEAT 1238..1239
FT /note="2-3"
FT REPEAT 1241..1242
FT /note="3-3"
FT REPEAT 1243..1244
FT /note="4-3"
FT REPEAT 1245..1246
FT /note="5-3"
FT REPEAT 1247..1248
FT /note="6-3"
FT REPEAT 1250..1251
FT /note="7-3"
FT REGION 79..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..996
FT /note="5 X 2 AA tandem repeats of G-V"
FT REGION 1092..1107
FT /note="8 X 2 AA tandem repeats of V-G"
FT REGION 1162..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1252
FT /note="7 X 2 AA tandem repeats of G-V"
FT REGION 1362..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1486..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..228
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.5"
FT /id="VSP_014690"
FT VAR_SEQ 229..232
FT /note="SVHV -> MNIW (in isoform C)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.5"
FT /id="VSP_014691"
FT VAR_SEQ 652..661
FT /note="QQQQQQQQQA -> HKNIGDILNA (in isoform C)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.5"
FT /id="VSP_014692"
FT VAR_SEQ 662..1594
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.5"
FT /id="VSP_014693"
FT CONFLICT 20..21
FT /note="Missing (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="Q -> QQQ (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="A -> P (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="G -> N (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="Q -> QQQHQ (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="N -> S (in Ref. 5; AAZ41759)"
FT /evidence="ECO:0000305"
FT CONFLICT 700
FT /note="Q -> QQ (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 769..772
FT /note="Missing (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 800
FT /note="Missing (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 870
FT /note="A -> G (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 879
FT /note="A -> T (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 895
FT /note="Q -> QQ (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 919
FT /note="H -> Q (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 1076
FT /note="A -> V (in Ref. 5; AAZ41759)"
FT /evidence="ECO:0000305"
FT CONFLICT 1314
FT /note="A -> R (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 1401
FT /note="S -> T (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
FT CONFLICT 1432
FT /note="Q -> QQ (in Ref. 1; CAA38152)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1594 AA; 167261 MW; D4236DA26F70D092 CRC64;
MDAGGLPVFQ SASQAAAVAQ QQQQQQQQQQ QHLNLQLHQQ HLGLHLQQQQ QLQLQQQQHN
AQAQQQQIQV QQQQQQQQQQ QQQQHSPYNA NLGATGGIAG ITGGNGAGGP TNPGAVPTAP
GDTMPTKRMP VVDRLRRRME NYRRRQTDCV PRYEQAFNTV CEQQNQETTV LQKRFLESKN
KRAAKKTDKK LPDPSQQHQQ QQHQQQQQHQ QHQQHQQAQT MLAGQLQSSV HVQQKFLKRP
AEDVDNGPDS FEPPHKLPNN NNNSNSNNNN GNANANNGGN GSNTGNNTNN NGNSTNNNGG
SNNNGSENLT KFSVEIVQQL EFTTSAANSQ PQQISTNVTV KALTNTSVKS EPGVGGGGGG
GGGGGSGNNN NNGGGGGGGN GNNNNNGGDH HQQQHQQQQQ QQGGGLGGLG NNGRGGGPGG
MATGPGGVAG GLGGMGMPPN MMSAQQKSAL GNLANLVECK REPDHDFPDL GSLDKDGGGG
QFPGFPDLLG DDNSENNDTF KDLINNLQDF NPSFLDGFDE KPLLDIKTED GIKVEPPNAQ
DLINSLNVKS EGGLGHGFGG FGLGLDNPGM KMRGGNPGNQ GGFPNGPNGG TGGAPNAGGN
GGNSGNLMSE HPLAAQTLKQ MAEQHQHKNA MGGMGGFPRP PHGMNPQQQQ QQQQQQQQQQ
AQQQHGQMMG QGQPGRYNDY GGGFPNDFGL GPNGPQQQQQ AQQQQPQQQH LPPQFHQQKG
PGPGAGMNVQ QNFLDIKQEL FYSSQNDFDL KRLQQQQAMQ QQQQQQHHQQ QQQQQQPKMG
GVPNFNKQQQ QQQVPQQQLQ QQQQQQQQQQ QQQQQQYSPF SNQNPNAAAN FLNCPPRGGP
NGNQQPGNLA QQQQQPGAGP QQQQQRGNAA NGQQNNPNAG PGGNTPNAPQ QQQQQSTTTT
LQMKQTQQLH ISQQGGGAHG IQVSAGQHLH LSGDMKSNVS VAAQQGVFFS QQQAQQQQQQ
QQPGGTNGPN PQQQQQQPHG GNAGGGVGVG VGVGVGNGGP NPGQQQQQPN QNMSNANVPS
DGFSLSQSQS MNFNQQQQQQ AAAQQQQVQP NMRQRQTQAQ AAAAAAAAAA QAQAAANASG
PNVPLMQQPQ VGVGVGVGVG VGVGVGNGGV VGGPGSGGPN NGAMNQMGGP MGGMPGMQMG
GPMNPMQMNP NAAGPTAQQM MMGSGAGGPG QVPGPGQGPN PNQAKFLQQQ QMMRAQAMQQ
QQQHMSGARP PPPEYNATKA QLMQAQMMQQ TVGGGGVGVG GVGVGVGVGG VGGANGGRFP
NSAAQAAAMR RMTQQPIPPS GPMMRPQHAM YMQQHGGAGG GPRTGMGVPY GGGAGGPMGG
PQQQQRPPNV QVTPDGMPMG SQQEWRHMMM TQQQTQMGFG GPGPGGPMRQ GPGGFNGGNF
MPNGAPNGAA GSGPNAGGMM SGPNVPQMQL TPAQMQQQLM RQQQQQQQQQ QQHMGPGAAN
NMQMQQLLQQ QQSGGGGNMM ASQMQMTSMH MTQTQQQITM QQQQQFVQST TTTTHQQQQM
MQMGPGGGGG GGGPGSANNN NGGGGGGAAG GGNSASTIAS ASSISQTINS VVANSNDFGL
EFLDNLPVDS NFSTQDLINS LDNDNFNLQD FNMP
