MANBL_HUMAN
ID MANBL_HUMAN Reviewed; 85 AA.
AC Q9NQG1; A8KAA6; E1P5V3;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein MANBAL;
GN Name=MANBAL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q9NQG1; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-3867271, EBI-12069500;
CC Q9NQG1; Q8TAZ6: CMTM2; NbExp=3; IntAct=EBI-3867271, EBI-2339374;
CC Q9NQG1; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-3867271, EBI-11955647;
CC Q9NQG1; Q9Y337: KLK5; NbExp=3; IntAct=EBI-3867271, EBI-9057524;
CC Q9NQG1; Q13021: MALL; NbExp=3; IntAct=EBI-3867271, EBI-750078;
CC Q9NQG1; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-3867271, EBI-2341610;
CC Q9NQG1; O75352: MPDU1; NbExp=3; IntAct=EBI-3867271, EBI-1046501;
CC Q9NQG1; Q6P499: NIPAL3; NbExp=3; IntAct=EBI-3867271, EBI-10252783;
CC Q9NQG1; Q7RTS6: OTOP2; NbExp=3; IntAct=EBI-3867271, EBI-7642372;
CC Q9NQG1; Q07326: PIGF; NbExp=3; IntAct=EBI-3867271, EBI-17180304;
CC Q9NQG1; O75711: SCRG1; NbExp=3; IntAct=EBI-3867271, EBI-10189029;
CC Q9NQG1; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-3867271, EBI-2823239;
CC Q9NQG1; Q13277: STX3; NbExp=3; IntAct=EBI-3867271, EBI-1394295;
CC Q9NQG1; P55061: TMBIM6; NbExp=3; IntAct=EBI-3867271, EBI-1045825;
CC Q9NQG1; Q12893: TMEM115; NbExp=3; IntAct=EBI-3867271, EBI-8633987;
CC Q9NQG1; Q969S6: TMEM203; NbExp=3; IntAct=EBI-3867271, EBI-12274070;
CC Q9NQG1; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-3867271, EBI-17180389;
CC Q9NQG1; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-3867271, EBI-10173939;
CC Q9NQG1; Q9BQB6: VKORC1; NbExp=3; IntAct=EBI-3867271, EBI-6256462;
CC Q9NQG1; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-3867271, EBI-723716;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0239 family. {ECO:0000305}.
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DR EMBL; AK292971; BAF85660.1; -; mRNA.
DR EMBL; AL034422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76069.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76070.1; -; Genomic_DNA.
DR EMBL; BC014672; AAH14672.1; -; mRNA.
DR EMBL; BC016822; AAH16822.1; -; mRNA.
DR CCDS; CCDS13293.1; -.
DR RefSeq; NP_001003897.1; NM_001003897.1.
DR RefSeq; NP_071360.1; NM_022077.3.
DR RefSeq; XP_016883495.1; XM_017028006.1.
DR RefSeq; XP_016883496.1; XM_017028007.1.
DR AlphaFoldDB; Q9NQG1; -.
DR SMR; Q9NQG1; -.
DR BioGRID; 121981; 28.
DR IntAct; Q9NQG1; 23.
DR STRING; 9606.ENSP00000362707; -.
DR iPTMnet; Q9NQG1; -.
DR PhosphoSitePlus; Q9NQG1; -.
DR BioMuta; MANBAL; -.
DR DMDM; 30316137; -.
DR EPD; Q9NQG1; -.
DR jPOST; Q9NQG1; -.
DR MassIVE; Q9NQG1; -.
DR MaxQB; Q9NQG1; -.
DR PaxDb; Q9NQG1; -.
DR PeptideAtlas; Q9NQG1; -.
DR PRIDE; Q9NQG1; -.
DR ProteomicsDB; 82147; -.
DR TopDownProteomics; Q9NQG1; -.
DR Antibodypedia; 43449; 52 antibodies from 13 providers.
DR DNASU; 63905; -.
DR Ensembl; ENST00000373605.7; ENSP00000362707.3; ENSG00000101363.13.
DR Ensembl; ENST00000373606.8; ENSP00000362708.3; ENSG00000101363.13.
DR Ensembl; ENST00000397151.1; ENSP00000380338.1; ENSG00000101363.13.
DR Ensembl; ENST00000397152.7; ENSP00000380339.3; ENSG00000101363.13.
DR GeneID; 63905; -.
DR KEGG; hsa:63905; -.
DR MANE-Select; ENST00000373606.8; ENSP00000362708.3; NM_001003897.2; NP_001003897.1.
DR UCSC; uc002xgv.4; human.
DR CTD; 63905; -.
DR GeneCards; MANBAL; -.
DR HGNC; HGNC:15799; MANBAL.
DR HPA; ENSG00000101363; Low tissue specificity.
DR neXtProt; NX_Q9NQG1; -.
DR OpenTargets; ENSG00000101363; -.
DR PharmGKB; PA30578; -.
DR VEuPathDB; HostDB:ENSG00000101363; -.
DR eggNOG; ENOG502S6QI; Eukaryota.
DR GeneTree; ENSGT00390000003422; -.
DR HOGENOM; CLU_189363_0_0_1; -.
DR InParanoid; Q9NQG1; -.
DR OMA; KMDTESF; -.
DR OrthoDB; 1597344at2759; -.
DR PhylomeDB; Q9NQG1; -.
DR TreeFam; TF324668; -.
DR PathwayCommons; Q9NQG1; -.
DR SignaLink; Q9NQG1; -.
DR BioGRID-ORCS; 63905; 15 hits in 1040 CRISPR screens.
DR ChiTaRS; MANBAL; human.
DR GenomeRNAi; 63905; -.
DR Pharos; Q9NQG1; Tdark.
DR PRO; PR:Q9NQG1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NQG1; protein.
DR Bgee; ENSG00000101363; Expressed in thoracic aorta and 182 other tissues.
DR ExpressionAtlas; Q9NQG1; baseline and differential.
DR Genevisible; Q9NQG1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009621; UPF0239.
DR PANTHER; PTHR14409; PTHR14409; 1.
DR Pfam; PF06783; UPF0239; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..85
FT /note="Protein MANBAL"
FT /id="PRO_0000194179"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 48..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 85 AA; 9467 MW; 8EB01B680C9C06A9 CRC64;
MASDLDFSPP EVPEPTFLEN LLRYGLFLGA IFQLICVLAI IVPIPKSHEA EAEPSEPRSA
EVTRKPKAAV PSVNKRPKKE TKKKR
