ID   MANBP_PSEAE             Reviewed;         436 AA.
AC   Q9I1E0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Mannitol-binding protein {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=PA2338 {ECO:0000312|EMBL:AAG05726.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION AS A BINDING PROTEIN.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=31627455; DOI=10.3390/ijms20205156;
RA   Fernandez M., Rico-Jimenez M., Ortega A., Daddaoua A., Garcia Garcia A.I.,
RA   Martin-Mora D., Torres N.M., Tajuelo A., Matilla M.A., Krell T.;
RT   "Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding
RT   Proteins.";
RL   Int. J. Mol. Sci. 20:5156-5156(2019).
CC   -!- FUNCTION: Binds mannitol with high affinity.
CC       {ECO:0000269|PubMed:31627455}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG05726.1; -; Genomic_DNA.
DR   PIR; H83352; H83352.
DR   RefSeq; NP_251028.1; NC_002516.2.
DR   RefSeq; WP_003105362.1; NZ_QZGE01000021.1.
DR   AlphaFoldDB; Q9I1E0; -.
DR   SMR; Q9I1E0; -.
DR   STRING; 287.DR97_6094; -.
DR   PaxDb; Q9I1E0; -.
DR   EnsemblBacteria; AAG05726; AAG05726; PA2338.
DR   GeneID; 883086; -.
DR   KEGG; pae:PA2338; -.
DR   PATRIC; fig|208964.12.peg.2446; -.
DR   PseudoCAP; PA2338; -.
DR   HOGENOM; CLU_031285_9_0_6; -.
DR   InParanoid; Q9I1E0; -.
DR   OMA; ESSMTYY; -.
DR   PhylomeDB; Q9I1E0; -.
DR   BioCyc; PAER208964:G1FZ6-2377-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006059; SBP.
DR   Pfam; PF01547; SBP_bac_1; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..436
FT                   /note="Mannitol-binding protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004327403"
SQ   SEQUENCE   436 AA;  47324 MW;  B0FFC6F841113E9C CRC64;
     MNDSIKACLA AACLALPLLA QGAETLTIAT VNNNDMIRMQ RLSKVFEESH PDIALKWVVL
     EENVLRQRLT TDIATQGGQF DLLTIGMYEA ALWGAKGWLE PMSGLPADYA LDDLLPSVRD
     GLSVKGTLYA LPFYAEASIT YYRKDLFQQA GLRMPEQPTW TQLGEFAARL NRPDQGQYGI
     CLRGKAGWGE NMALIGTLAN AFGARWFDER WQPEFSGGEW KKALDFYVST LKRYGPPGAS
     SNGFNENLAL FNSGKCAIWV DASVAGSFVT DKSQSKVADA TGFAFAPREV TDKGASWLYS
     WALAIPASSR AKDAAKAFAT WATSQAYGKL VADREGVANV PPGTRASTYS EAYLAAAPFA
     RVTLESLKRV DPNHPTLKPV PYVGIQLVTI PEFQAIGTQV GKLFSAALTG QMSSDQALAA
     AQQSTAREMK RAGYPK