ID   MANC_SALMO              Reviewed;         471 AA.
AC   Q01410;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Mannose-1-phosphate guanylyltransferase;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
DE            Short=GMP;
DE            Short=GMPP;
GN   Name=manC; Synonyms=rfbM;
OS   Salmonella montevideo.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=115981;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M40;
RX   PubMed=1383393; DOI=10.1099/00221287-138-9-1843;
RA   Lee S.J., Romana L.K., Reeves P.R.;
RT   "Sequence and structural analysis of the rfb (O antigen) gene cluster from
RT   a group C1 Salmonella enterica strain.";
RL   J. Gen. Microbiol. 138:1843-1855(1992).
CC   -!- FUNCTION: Involved in GDP-mannose biosynthesis which serves as the
CC       activated sugar nucleotide precursor for mannose residues in cell
CC       surface polysaccharides. This enzyme participates in synthesis of the
CC       LPS O antigen.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; M84642; AAB49390.1; -; Genomic_DNA.
DR   PIR; S27676; S27676.
DR   AlphaFoldDB; Q01410; -.
DR   SMR; Q01410; -.
DR   UniPathway; UPA00126; UER00930.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.10; -; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01479; GMP_PMI; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Lipopolysaccharide biosynthesis; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..471
FT                   /note="Mannose-1-phosphate guanylyltransferase"
FT                   /id="PRO_0000194256"
SQ   SEQUENCE   471 AA;  52634 MW;  56CFB825278FE0B7 CRC64;
     MITPIIMAGG NGSRLWPLSR TLYPKQFLCL DGSQSMLQTT ITRINNLNAS DPIVICNEQH
     RFIVAEQLKE LSKSSGDIIL EPVGRNTAPA VALAALKCLK KNALLLVLAA DHIIKDEETF
     CKTIQDARKY AEAGKLVTFG IVPTMPETGY GYIRRGQALF SAENDCSLAF RVAEFVEKPN
     LETAQSYLDS GEYYWNSGMF LFRADRYIEE LKIRPDIYKA CSLAMESAVT DLDFIRVDED
     SFCACPDESI DYAVMEKTND AVVVPLNAGW SDVGSWSSLW EISDKDSNGN VTKGDVLSHN
     ADNCYLHAET GLVTAVGVKD LIVVQTKDAV LVANTNCVQD VKKIVEKIKL ENRHEHITHR
     EVYRPWGKYD SIDFGERYQV KRITVKPGEG ISEQQHYHRA EHWIIVAGTA KITIKGEVKI
     LTENESVYIP VGVKHCLENP GKIALELIEV RSGAYLGEDD IVRFSDKYGR N