ID   MANC_SALTY              Reviewed;         480 AA.
AC   P26340;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Mannose-1-phosphate guanylyltransferase ManC;
DE            EC=2.7.7.13;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
DE            Short=GMP;
DE            Short=GMPP;
GN   Name=manC; Synonyms=cpsB; OrderedLocusNames=STM2105;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1712067; DOI=10.1007/bf00259668;
RA   Stevenson G., Lee S.J., Romana L.K., Reeves P.R.;
RT   "The cps gene cluster of Salmonella strain LT2 includes a second mannose
RT   pathway: sequence of two genes and relationship to genes in the rfb gene
RT   cluster.";
RL   Mol. Gen. Genet. 227:173-180(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in the biosynthesis of the capsular polysaccharide
CC       colanic acid.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC       biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; X59886; CAA42540.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21009.1; -; Genomic_DNA.
DR   PIR; S16290; S16290.
DR   RefSeq; NP_461050.3; NC_003197.2.
DR   RefSeq; WP_000605938.1; NC_003197.2.
DR   AlphaFoldDB; P26340; -.
DR   SMR; P26340; -.
DR   STRING; 99287.STM2105; -.
DR   PaxDb; P26340; -.
DR   EnsemblBacteria; AAL21009; AAL21009; STM2105.
DR   GeneID; 1253626; -.
DR   KEGG; stm:STM2105; -.
DR   HOGENOM; CLU_035527_1_0_6; -.
DR   OMA; LIVCNEK; -.
DR   PhylomeDB; P26340; -.
DR   BioCyc; SENT99287:STM2105-MON; -.
DR   UniPathway; UPA00126; UER00930.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009298; P:GDP-mannose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.10; -; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01479; GMP_PMI; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; GTP-binding;
KW   Lipopolysaccharide biosynthesis; Nucleotide-binding;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..480
FT                   /note="Mannose-1-phosphate guanylyltransferase ManC"
FT                   /id="PRO_0000194257"
SQ   SEQUENCE   480 AA;  53370 MW;  C1F09C66B04CDBD6 CRC64;
     MIMRQTKLYP VVMAGGSGSR LWPLSRVLYP KQFLCLKGDL TMLQTTICRL NGVECESPLV
     ICNEQHRFIV AEQLRQLNKL TENIILEPAG RNTAPAIALA ALAATRQHTD CDPLMLVLAA
     DHAIANEEAF RDAVRGAMPY ADAGKLVTFG IVPDLPETGY GYIRRGDVVP GATDAVAFEV
     AQFVEKPGLE TAQAYVASGD YYWNSGMFLF RAGRYLEELK KFRPDILAAC EQAMRGVDPD
     LDFIRVDEEA FLACPEESID YAVMERTADA VVMPMDAGWS DVGSWSSLWE ISAHTPEGNV
     HHGDVISHKT ENSYVYAESG LVTTVGVKDL VVVQTKDAVL IADRHAVQDV KKVVEKIKAD
     GRHEHHMHRE VYRPWGKYDS IDAGERYQVK RITVKPGEGL SVQMHHHRAE HWVVVAGTAR
     VTINGEVKLL GENESIYIPL GATHCLENPG KIPLDLIEVR SGSYLEEDDV VRFEDRYGRV