MANEL_DANRE
ID MANEL_DANRE Reviewed; 442 AA.
AC Q1L8D2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Glycoprotein endo-alpha-1,2-mannosidase-like protein;
DE EC=3.2.1.-;
GN Name=maneal; ORFNames=si:ch211-30b16.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 99 family. {ECO:0000305}.
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DR EMBL; CR925717; CAK04938.1; -; Genomic_DNA.
DR RefSeq; NP_001038579.1; NM_001045114.1.
DR AlphaFoldDB; Q1L8D2; -.
DR SMR; Q1L8D2; -.
DR STRING; 7955.ENSDARP00000073408; -.
DR CAZy; GH99; Glycoside Hydrolase Family 99.
DR PaxDb; Q1L8D2; -.
DR Ensembl; ENSDART00000078951; ENSDARP00000073408; ENSDARG00000056450.
DR GeneID; 566679; -.
DR KEGG; dre:566679; -.
DR CTD; 149175; -.
DR ZFIN; ZDB-GENE-060503-511; maneal.
DR eggNOG; ENOG502QPJV; Eukaryota.
DR GeneTree; ENSGT00390000016054; -.
DR HOGENOM; CLU_042710_1_1_1; -.
DR InParanoid; Q1L8D2; -.
DR OMA; YGNHGAF; -.
DR OrthoDB; 975667at2759; -.
DR PhylomeDB; Q1L8D2; -.
DR TreeFam; TF324051; -.
DR PRO; PR:Q1L8D2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000056450; Expressed in brain and 8 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004559; F:alpha-mannosidase activity; IBA:GO_Central.
DR CDD; cd11574; GH99; 1.
DR InterPro; IPR026071; Glyco_Hydrolase_99.
DR PANTHER; PTHR13572; PTHR13572; 1.
DR Pfam; PF16317; Glyco_hydro_99; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..442
FT /note="Glycoprotein endo-alpha-1,2-mannosidase-like
FT protein"
FT /id="PRO_0000282322"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..442
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 442 AA; 50313 MW; 5C587AB7AD0AB667 CRC64;
MNRLRRKACV ALLLFTLFIF GTMMGLRTLK PTDGFSDLAP GMELMPLVGE RMEQRPNHLI
ESAGQNGGLH SDTKIVFSNS GPDHSIFYDI HIFYYLWYGS PQMDSSYIHW DHVLVPHWDP
KIAASHPKGR HNPPDDIASS YYPELGPYSS RDPEVIESHM AQIEAAAAGV VVLSWYPPGV
ADEHGKPSED LVPAVMDAAH KHSIKVAFHL QPYKGRTDIS VHDNIKYIID TYGTHGAFYR
FKSSTGKILP LFYVYDSYLT PPETWAELLT IRGSHSLRGT PYDGIFIALI VEERHKQDIL
AGGFDGMYTY FASNGFSFGS SHQNWKAIKA FCDKNNLLFV PSAGPGYMDT AVRPWNNHNT
RNRVNGRYYE TSLQAAMSVR PDIITITSFN EWHEGTQIER AVPKKTVARL YLDYKPHQPD
HYLELTKKWA EHFSKEKEQW LM
