MANS1_MOUSE
ID MANS1_MOUSE Reviewed; 414 AA.
AC Q9CR33; Q80V71;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=MANSC domain-containing protein 1;
DE Flags: Precursor;
GN Name=Mansc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Colon, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK018660; BAB31329.1; -; mRNA.
DR EMBL; AK018635; BAB31319.1; -; mRNA.
DR EMBL; AK033526; BAC28341.1; -; mRNA.
DR EMBL; AK033557; BAC28357.1; -; mRNA.
DR EMBL; AK046837; BAC32892.1; -; mRNA.
DR EMBL; BC039930; AAH39930.1; -; mRNA.
DR CCDS; CCDS20637.1; -.
DR RefSeq; NP_080621.1; NM_026345.4.
DR AlphaFoldDB; Q9CR33; -.
DR SMR; Q9CR33; -.
DR STRING; 10090.ENSMUSP00000038346; -.
DR GlyGen; Q9CR33; 3 sites.
DR iPTMnet; Q9CR33; -.
DR PhosphoSitePlus; Q9CR33; -.
DR MaxQB; Q9CR33; -.
DR PaxDb; Q9CR33; -.
DR PRIDE; Q9CR33; -.
DR ProteomicsDB; 287309; -.
DR ABCD; Q9CR33; 12 sequenced antibodies.
DR Antibodypedia; 2339; 119 antibodies from 24 providers.
DR DNASU; 67729; -.
DR Ensembl; ENSMUST00000047443; ENSMUSP00000038346; ENSMUSG00000032718.
DR GeneID; 67729; -.
DR KEGG; mmu:67729; -.
DR UCSC; uc009ekm.2; mouse.
DR CTD; 54682; -.
DR MGI; MGI:1914979; Mansc1.
DR VEuPathDB; HostDB:ENSMUSG00000032718; -.
DR eggNOG; ENOG502RZBP; Eukaryota.
DR GeneTree; ENSGT00940000153377; -.
DR HOGENOM; CLU_054219_0_0_1; -.
DR InParanoid; Q9CR33; -.
DR OMA; SQNCPTK; -.
DR OrthoDB; 778983at2759; -.
DR PhylomeDB; Q9CR33; -.
DR TreeFam; TF336966; -.
DR BioGRID-ORCS; 67729; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Mansc1; mouse.
DR PRO; PR:Q9CR33; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CR33; protein.
DR Bgee; ENSMUSG00000032718; Expressed in parotid gland and 164 other tissues.
DR Genevisible; Q9CR33; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR Pfam; PF07502; MANEC; 1.
DR SMART; SM00765; MANEC; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..414
FT /note="MANSC domain-containing protein 1"
FT /id="PRO_0000021638"
FT TOPO_DOM 25..369
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 393..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..116
FT /note="MANSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00341"
FT REGION 311..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 335
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 11..13
FT /note="SLL -> ALV (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 56
FT /note="L -> V (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="I -> V (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="F -> S (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="R -> G (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="M -> T (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="E -> A (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="G -> A (in Ref. 2; AAH39930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 414 AA; 44823 MW; 29BB9197C916BA8E CRC64;
MLFRGTSLAY SLLVISFLTP RSSAGQNCLT KSLEDVVIDI QSSLSKGIRG NEPIHLATQE
DCIGACCSTK DIAGDKACNL MIFDTRKTDR QPNCYLFFCP SEDACPLKPA KGLVTYRLIR
DFPLTSANSS LQQLTQGEFL LLDHSSPGAT PGFRTPAGYP KPTGLSWSDR SSLKSTAPLH
LRKHIKADET SMQLPEEKSH SQSLQLPSEL KMAHLLPKTV PTPPTTVAVA PLRNVSATLK
PELLLTSISV TAKTLKQKEA TTASPVTTVT SKLPGVPGST SFTPVVTHQA ALTNTFQAHT
DSKGILETMP FQGGSTLTSD PRHGKSSTSE SSITNKTASW EDRRVSVGSA SLNKGPKSQH
GLSFEKWLLI GTLLCGVLFL VIGLVLLGRM LVEALRRKRY SRLDYLINGI YVDI
