MANS4_HUMAN
ID MANS4_HUMAN Reviewed; 340 AA.
AC A6NHS7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=MANSC domain-containing protein 4;
DE Flags: Precursor;
GN Name=MANSC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC009509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53770.1; -.
DR RefSeq; NP_001139693.1; NM_001146221.1.
DR AlphaFoldDB; A6NHS7; -.
DR BioGRID; 938946; 2.
DR STRING; 9606.ENSP00000370673; -.
DR GlyGen; A6NHS7; 3 sites.
DR iPTMnet; A6NHS7; -.
DR PhosphoSitePlus; A6NHS7; -.
DR BioMuta; MANSC4; -.
DR PaxDb; A6NHS7; -.
DR PRIDE; A6NHS7; -.
DR ProteomicsDB; 1224; -.
DR Antibodypedia; 49381; 9 antibodies from 5 providers.
DR DNASU; 100287284; -.
DR Ensembl; ENST00000381273.4; ENSP00000370673.3; ENSG00000205693.4.
DR GeneID; 100287284; -.
DR KEGG; hsa:100287284; -.
DR MANE-Select; ENST00000381273.4; ENSP00000370673.3; NM_001146221.5; NP_001139693.1.
DR UCSC; uc010sjs.2; human.
DR CTD; 100287284; -.
DR DisGeNET; 100287284; -.
DR GeneCards; MANSC4; -.
DR HGNC; HGNC:40023; MANSC4.
DR HPA; ENSG00000205693; Tissue enhanced (testis).
DR neXtProt; NX_A6NHS7; -.
DR VEuPathDB; HostDB:ENSG00000205693; -.
DR eggNOG; ENOG502RZQD; Eukaryota.
DR GeneTree; ENSGT00940000153377; -.
DR HOGENOM; CLU_071212_0_0_1; -.
DR InParanoid; A6NHS7; -.
DR OMA; DTKLSHM; -.
DR OrthoDB; 1127205at2759; -.
DR PhylomeDB; A6NHS7; -.
DR TreeFam; TF353070; -.
DR SignaLink; A6NHS7; -.
DR BioGRID-ORCS; 100287284; 12 hits in 1062 CRISPR screens.
DR Pharos; A6NHS7; Tdark.
DR PRO; PR:A6NHS7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A6NHS7; protein.
DR Bgee; ENSG00000205693; Expressed in cerebellar hemisphere and 64 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR Pfam; PF07502; MANEC; 1.
DR SMART; SM00765; MANEC; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..340
FT /note="MANSC domain-containing protein 4"
FT /id="PRO_0000349176"
FT TOPO_DOM 25..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 37..117
FT /note="MANSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00341"
FT REGION 320..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 37879 MW; 4C5393FDA04AFB87 CRC64;
MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK LGAQFLKYYS
ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC PTLESCILEP GTSAILYNIT
DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ
DLVVNTNSTS YSKELTTDFW ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID
TKLSHMPVPP GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC
CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS
