MANS4_MOUSE
ID MANS4_MOUSE Reviewed; 337 AA.
AC Q3UU94; B2KFS6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=MANSC domain-containing protein 4;
DE Flags: Precursor;
GN Name=Mansc4; Synonyms=Gm5887;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NOD/LtJ;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK138652; BAE23733.1; -; mRNA.
DR EMBL; CU207396; CAQ51867.1; -; Genomic_DNA.
DR CCDS; CCDS20705.1; -.
DR RefSeq; NP_001030075.1; NM_001034903.3.
DR AlphaFoldDB; Q3UU94; -.
DR SMR; Q3UU94; -.
DR STRING; 10090.ENSMUSP00000098343; -.
DR GlyGen; Q3UU94; 3 sites.
DR iPTMnet; Q3UU94; -.
DR PhosphoSitePlus; Q3UU94; -.
DR PaxDb; Q3UU94; -.
DR PRIDE; Q3UU94; -.
DR ProteomicsDB; 295812; -.
DR Antibodypedia; 49381; 9 antibodies from 5 providers.
DR Ensembl; ENSMUST00000100780; ENSMUSP00000098343; ENSMUSG00000072662.
DR GeneID; 545893; -.
DR KEGG; mmu:545893; -.
DR UCSC; uc009est.1; mouse.
DR CTD; 100287284; -.
DR MGI; MGI:3645619; Mansc4.
DR VEuPathDB; HostDB:ENSMUSG00000072662; -.
DR eggNOG; ENOG502RZQD; Eukaryota.
DR GeneTree; ENSGT00940000153377; -.
DR HOGENOM; CLU_071212_0_0_1; -.
DR InParanoid; Q3UU94; -.
DR OMA; DTKLSHM; -.
DR OrthoDB; 1127205at2759; -.
DR PhylomeDB; Q3UU94; -.
DR TreeFam; TF353070; -.
DR BioGRID-ORCS; 545893; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q3UU94; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q3UU94; protein.
DR Bgee; ENSMUSG00000072662; Expressed in right kidney and 54 other tissues.
DR ExpressionAtlas; Q3UU94; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR Pfam; PF07502; MANEC; 1.
DR SMART; SM00765; MANEC; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..337
FT /note="MANSC domain-containing protein 4"
FT /id="PRO_0000349177"
FT TOPO_DOM 19..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 33..113
FT /note="MANSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00341"
FT REGION 216..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 136
FT /note="S -> T (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="S -> T (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="P -> S (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="A -> P (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="T -> I (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="L -> I (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="N -> T (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="K -> N (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="W -> R (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="I -> V (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="R -> Q (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="R -> H (in Ref. 2; CAQ51867)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 36857 MW; D25BF9E348175E0D CRC64;
MRAVELLLLL GLASMVHGLC SPTVFYRDCW IRRFPGMLLD LEESQRLGAQ FLKYYSENTG
QKCGRSCCLR KDVSCNVAVF FHDPVHDNVN CLHVHCPTLE SCILEPGASA ILYNITAGID
PDLLVFEHTS PIYPNSRSSS EWWDRLRILK AMSVGSEGVY PDVMNRMVPS TEAASTTQQD
LGANTGISYS RKSTTDVGLR FTSANVSTAT KVNMVSPSTD FTHSPGNKTI SPFFGPTDTR
VSQVPSRSRL NISKPSVNKT KGSHSRNHSS ENEEPWDGAP ASAGVWLACV TLGAAVISLC
CRVVLGTSRC CGKRQGWSHM GQRSASGCRR NTLKENS
