MAP10_BOVIN
ID MAP10_BOVIN Reviewed; 912 AA.
AC A3KMW7;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Microtubule-associated protein 10;
DE AltName: Full=Microtubule regulator of 120 KDa;
GN Name=MAP10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-associated protein (MAP) that plays a role in the
CC regulation of cell division; promotes microtubule stability and
CC participates in the organization of the spindle midzone and normal
CC progress of cytokinesis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via middle region) with microtubules.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome {ECO:0000250}. Midbody
CC {ECO:0000250}. Note=Localized at stabilized microtubules (MTs) during
CC interphase and to the mitotic apparatus during mitosis. Localized at
CC spindle poles in metaphase and spindle midzone during telophase.
CC Colocalized with Polo-like kinase PLK1 to the center of spindle
CC midzone. Localized at the midbody during cytokinesis. Colocalized with
CC acetylated-tubulin at MTs (By similarity). {ECO:0000250}.
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DR EMBL; BC133339; AAI33340.1; -; mRNA.
DR RefSeq; NP_001091617.1; NM_001098148.1.
DR AlphaFoldDB; A3KMW7; -.
DR STRING; 9913.ENSBTAP00000016680; -.
DR PaxDb; A3KMW7; -.
DR PRIDE; A3KMW7; -.
DR Ensembl; ENSBTAT00000016680; ENSBTAP00000016680; ENSBTAG00000012566.
DR GeneID; 781199; -.
DR KEGG; bta:781199; -.
DR CTD; 54627; -.
DR VEuPathDB; HostDB:ENSBTAG00000012566; -.
DR VGNC; VGNC:31176; MAP10.
DR eggNOG; ENOG502QVBX; Eukaryota.
DR GeneTree; ENSGT00390000008459; -.
DR HOGENOM; CLU_014844_0_0_1; -.
DR InParanoid; A3KMW7; -.
DR OMA; MLVVHEK; -.
DR OrthoDB; 486802at2759; -.
DR TreeFam; TF338644; -.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000012566; Expressed in spermatid and 104 other tissues.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:1990023; C:mitotic spindle midzone; ISS:UniProtKB.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:UniProtKB.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; ISS:UniProtKB.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
DR GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR InterPro; IPR039302; MAP10.
DR InterPro; IPR026679; MAP10_C-term.
DR PANTHER; PTHR21831; PTHR21831; 1.
DR Pfam; PF14925; HPHLAWLY; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..912
FT /note="Microtubule-associated protein 10"
FT /id="PRO_0000403446"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 100058 MW; 1667D79478407537 CRC64;
MASAVSERLF SLELLVDWVC LEAGLPQPPV VAEEEQKEEG EGASPPRPSR SLCPAVAFRL
LDFPTLLIYP PAGPAAPAQE SRPGLVSFRR GKSCLFRLQP ATLHRLLLRT PLYTLLLQLP
PGHPTPAPQL LGACSISLAA AVHKVLGFAA PGSSQSHRGS FPLCNRDGER IGDIALGYRL
SDLGSSLLGH LERPVASPGG GVEGMEVQKS VEVSPQTWQE NQQLQQPDSE PSPGDADKPL
VDVKISRAGK DLKGRAFHSK ADSDYTDSME NGKTNSDMCS KGSSERSVSP PNQEGTEVEL
ETNIICPPPL YYTHLTQEKT PPKQGKITIE PQINASEEWD DGTFLKENVN PPTHTNPPEH
TNSATGESCS VLINPASVQD TGASNQTTDH PPTEQNRINT IRQLPLLNAL LVELSLLYNQ
PMANPTHIHP HLAWLYRTED KKSPESSVKS TCKSESKKDK LSVGENEKSV SLQYKKNQTE
NLKKGKYFEK KGGAPQKRVS RGKLLYGLTN TLKLRLKQTN PDMLVEYEKK EQYKKMQTQM
LGAKLRIPSS KVKILSFAEL YQKPHELPKD KCLESDASFA ENSNTSKQIS VVVDDPSTTT
ETKLNCATEK TVDCDENRSN NGFLGEILSP ANSVVSERFI CTNTLEGKVF GRKSIQSPGV
FQQVAVVDRT VVDKEIDDKQ VKITGDDILT VDINEKNPST SSCSESISEL KYSDDFTSPC
SSEDTSRILR ACDSSPGTEN PKNSQHTSTS SETRLSIRKN SSAKSSILSP PFSAGSPVLS
HKRFPVSKTQ DKSLEEASSS DFSSSQWTEE KENQRDQNSM HNSKVIKQDH DISAKPKTRT
GCKSSEKSQS PRTSQVSSYL PSNLSELELN VLDCSTLDHF EEDCDDLGSL NISKQCKDIC
ELVINKLPGY TV
