MAP10_HUMAN
ID MAP10_HUMAN Reviewed; 905 AA.
AC Q9P2G4; A8K2F1; Q32MI1; Q58EZ9; Q5VV83;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Microtubule-associated protein 10;
DE AltName: Full=Microtubule regulator of 120 KDa;
GN Name=MAP10; Synonyms=KIAA1383, MTR120;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH MICROTUBULES, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=23264731; DOI=10.1242/jcs.116137;
RA Fong K.W., Leung J.W., Li Y., Wang W., Feng L., Ma W., Liu D., Songyang Z.,
RA Chen J.;
RT "MTR120/KIAA1383, a novel microtubule-associated protein, promotes
RT microtubule stability and ensures cytokinesis.";
RL J. Cell Sci. 126:825-837(2013).
CC -!- FUNCTION: Microtubule-associated protein (MAP) that plays a role in the
CC regulation of cell division; promotes microtubule stability and
CC participates in the organization of the spindle midzone and normal
CC progress of cytokinesis. {ECO:0000269|PubMed:23264731}.
CC -!- SUBUNIT: Interacts (via middle region) with microtubules.
CC {ECO:0000269|PubMed:23264731}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000269|PubMed:23264731}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000269|PubMed:23264731}. Midbody
CC {ECO:0000269|PubMed:23264731}. Note=Localized at stabilized
CC microtubules (MTs) during interphase and to the mitotic apparatus
CC during mitosis. Localized at spindle poles in metaphase and spindle
CC midzone during telophase. Colocalized with Polo-like kinase PLK1 to the
CC center of spindle midzone. Localized at the midbody during cytokinesis.
CC Colocalized with acetylated-tubulin at MTs.
CC -!- TISSUE SPECIFICITY: Expressed in different cell lines (at protein
CC level). {ECO:0000269|PubMed:23264731}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92621.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB037804; BAA92621.1; ALT_INIT; mRNA.
DR EMBL; AK290216; BAF82905.1; -; mRNA.
DR EMBL; AL451083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036663; AAH36663.1; -; mRNA.
DR EMBL; BC109122; AAI09123.2; -; mRNA.
DR CCDS; CCDS44334.1; -.
DR RefSeq; NP_061963.2; NM_019090.2.
DR AlphaFoldDB; Q9P2G4; -.
DR BioGRID; 120084; 31.
DR IntAct; Q9P2G4; 1.
DR STRING; 9606.ENSP00000403208; -.
DR GlyConnect; 1514; 11 N-Linked glycans (1 site).
DR GlyGen; Q9P2G4; 1 site, 11 N-linked glycans (1 site).
DR iPTMnet; Q9P2G4; -.
DR PhosphoSitePlus; Q9P2G4; -.
DR BioMuta; MAP10; -.
DR DMDM; 14286071; -.
DR EPD; Q9P2G4; -.
DR jPOST; Q9P2G4; -.
DR MassIVE; Q9P2G4; -.
DR PaxDb; Q9P2G4; -.
DR PeptideAtlas; Q9P2G4; -.
DR PRIDE; Q9P2G4; -.
DR ProteomicsDB; 83813; -.
DR Antibodypedia; 64568; 39 antibodies from 9 providers.
DR DNASU; 54627; -.
DR Ensembl; ENST00000418460.4; ENSP00000403208.2; ENSG00000212916.6.
DR GeneID; 54627; -.
DR KEGG; hsa:54627; -.
DR MANE-Select; ENST00000418460.4; ENSP00000403208.2; NM_019090.3; NP_061963.3.
DR UCSC; uc001hvh.3; human.
DR CTD; 54627; -.
DR DisGeNET; 54627; -.
DR GeneCards; MAP10; -.
DR HGNC; HGNC:29265; MAP10.
DR HPA; ENSG00000212916; Low tissue specificity.
DR MIM; 618551; gene.
DR neXtProt; NX_Q9P2G4; -.
DR OpenTargets; ENSG00000212916; -.
DR PharmGKB; PA142671610; -.
DR VEuPathDB; HostDB:ENSG00000212916; -.
DR eggNOG; ENOG502QVBX; Eukaryota.
DR GeneTree; ENSGT00390000008459; -.
DR HOGENOM; CLU_014844_0_0_1; -.
DR InParanoid; Q9P2G4; -.
DR OrthoDB; 486802at2759; -.
DR PhylomeDB; Q9P2G4; -.
DR TreeFam; TF338644; -.
DR PathwayCommons; Q9P2G4; -.
DR SignaLink; Q9P2G4; -.
DR BioGRID-ORCS; 54627; 7 hits in 1072 CRISPR screens.
DR ChiTaRS; MAP10; human.
DR GenomeRNAi; 54627; -.
DR Pharos; Q9P2G4; Tbio.
DR PRO; PR:Q9P2G4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9P2G4; protein.
DR Bgee; ENSG00000212916; Expressed in islet of Langerhans and 100 other tissues.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
DR GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR GO; GO:1990023; C:mitotic spindle midzone; IDA:UniProtKB.
DR GO; GO:0097431; C:mitotic spindle pole; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:UniProtKB.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; IMP:UniProtKB.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR GO; GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB.
DR InterPro; IPR039302; MAP10.
DR InterPro; IPR026679; MAP10_C-term.
DR PANTHER; PTHR21831; PTHR21831; 1.
DR Pfam; PF14925; HPHLAWLY; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..905
FT /note="Microtubule-associated protein 10"
FT /id="PRO_0000050794"
FT REGION 30..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 100345 MW; B02FBD0EDAD78491 CRC64;
MAASLSERLF SLELLVDWVR LEARLLPSPA AAVEQEEEEE EKEQGEASSP RGLCPAVAFR
LLDFPTLLVY PPDGPGAPAA EPWPGVIRFG RGKSCLFRLQ PATLHCRLLR TPLATLLLQL
PPGRPTPTPQ LLGACDISLA TAAHRVVGPA ASGCSHRHRG RFPLHNRVGE RTGDIALAYR
LTDLGSRLLS QLERPLTFTR TGGGAEVSPQ TQQERQQLQQ PASQPSPKEA DKPLGELEIP
EAQKDLKEMV KSKAECDNVG SVENGKTNSV VTCSGAGNGR NVSSLNEEVT ELDMETNIFC
PPPLYYTNLT QEKPPPAQAK ITIEPQMNAP EEMDDASPEK KRVNPPAHRS CLKHPSSAAH
EHPPMLVNPP HIQNIGATNQ TCQTEQNRIN TIRQLPLLNA LLVELSLLYD QPVTSPAHIH
PHLAWLYRTE DKKSPESSAK STCRSEAKKD KRSVGGCEKS VSLQYKKNQI ENYKEDKYSE
KSSGALHKRV PKGRLLYGLT NTLRLRLKLT NPDMLVVHEK RELYRKRQSQ MLGTKFRIPS
SKVKLLSSAE QSQKPQLPED KYLDSDASFT ENSDTSRQIS GVFDEPSTSK ETKLKYATEK
KTVDCSKNRI NNVSLEEVVS PANSIIPERL TPTNILGGNV EMKIQSPCVF QQDAVVDRIV
DKEIDIRQVK TTDNDILMAD ISDKRTGKNS CYENISELKY SDDLSSPCYS EDFCTSEDTS
RSFKAHDSSS RTENPKHSQY TSKSSDTGVS KKKNSSDRSS ILSPPFSAGS PVHSYRKFHI
SKTQDKSLEE ASSISASDLS STHWTEQKEN QIDQNSMHNS EITKRAQDIS VKTRSSWKSL
EKSQSPQTSQ VSSYLPSNVS ELNVLDSSTS DHFEEGNDDV GSLNISKQCK DICELVINKL
PGYTM
