MAP10_MOUSE
ID MAP10_MOUSE Reviewed; 891 AA.
AC Q8BJS7; Q5DTY2;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Microtubule-associated protein 10;
DE AltName: Full=Microtubule regulator of 120 KDa;
GN Name=Map10; Synonyms=Kiaa1383;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Microtubule-associated protein (MAP) that plays a role in the
CC regulation of cell division; promotes microtubule stability and
CC participates in the organization of the spindle midzone and normal
CC progress of cytokinesis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via middle region) with microtubules.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome {ECO:0000250}. Midbody
CC {ECO:0000250}. Note=Localized at stabilized microtubules (MTs) during
CC interphase and to the mitotic apparatus during mitosis. Localized at
CC spindle poles in metaphase and spindle midzone during telophase.
CC Colocalized with Polo-like kinase PLK1 to the center of spindle
CC midzone. Localized at the midbody during cytokinesis. Colocalized with
CC acetylated-tubulin at MTs (By similarity). {ECO:0000250}.
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DR EMBL; AK080043; BAC37814.1; -; mRNA.
DR EMBL; AK220388; BAD90253.1; -; mRNA.
DR EMBL; CH466525; EDL11801.1; -; Genomic_DNA.
DR CCDS; CCDS22780.1; -.
DR RefSeq; NP_083184.1; NM_028908.3.
DR AlphaFoldDB; Q8BJS7; -.
DR STRING; 10090.ENSMUSP00000061679; -.
DR PhosphoSitePlus; Q8BJS7; -.
DR PaxDb; Q8BJS7; -.
DR PRIDE; Q8BJS7; -.
DR ProteomicsDB; 295815; -.
DR Antibodypedia; 64568; 39 antibodies from 9 providers.
DR Ensembl; ENSMUST00000053078; ENSMUSP00000061679; ENSMUSG00000050930.
DR GeneID; 74393; -.
DR KEGG; mmu:74393; -.
DR UCSC; uc009nyi.2; mouse.
DR CTD; 54627; -.
DR MGI; MGI:1921643; Map10.
DR VEuPathDB; HostDB:ENSMUSG00000050930; -.
DR eggNOG; ENOG502QVBX; Eukaryota.
DR GeneTree; ENSGT00390000008459; -.
DR HOGENOM; CLU_014844_0_0_1; -.
DR InParanoid; Q8BJS7; -.
DR OMA; MLVVHEK; -.
DR OrthoDB; 486802at2759; -.
DR PhylomeDB; Q8BJS7; -.
DR TreeFam; TF338644; -.
DR BioGRID-ORCS; 74393; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8BJS7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BJS7; protein.
DR Bgee; ENSMUSG00000050930; Expressed in spermatocyte and 174 other tissues.
DR Genevisible; Q8BJS7; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:1990023; C:mitotic spindle midzone; ISS:UniProtKB.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:UniProtKB.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; ISS:UniProtKB.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
DR GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR InterPro; IPR039302; MAP10.
DR InterPro; IPR026679; MAP10_C-term.
DR PANTHER; PTHR21831; PTHR21831; 1.
DR Pfam; PF14925; HPHLAWLY; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..891
FT /note="Microtubule-associated protein 10"
FT /id="PRO_0000403447"
FT REGION 325..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 250
FT /note="K -> R (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
FT CONFLICT 453
FT /note="K -> R (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
FT CONFLICT 570
FT /note="R -> S (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
FT CONFLICT 588
FT /note="M -> L (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
FT CONFLICT 745
FT /note="S -> A (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
FT CONFLICT 883
FT /note="I -> N (in Ref. 2; BAD90253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 891 AA; 96155 MW; 471D83C532E85A55 CRC64;
MATTAAGRLF SLELLVDWVR LETGLSPCAA SPAVAFRLLD FPPLLVFPPA APGPEPQRGA
ISFGRGKACL LRLHPAALRR PRLRAALLQL PVGPTSAPGL VGACDILLVP SLGQRGVFAL
RGPEAERVGE LALFYRLTEL GRFSPGVPQL RGPLSPACIL DSEALEVSEP RTEETSKPCT
KGISARCLQC VSNARLLEGS EPCAKDTNSW SAGDSDASVV QKSWEEAVLH SKASSGDMAS
APCSPAPSGK TVSSVSQDVT ELDFETNTFC PPPLYYTHLT QEKTPSARVE ITIEPQRNEP
EDLDDIFPET KLVSPPLRPV KHTRAAVQES PPVLPNLPQT QGPGEANEAP CPPQIEQSPV
NAIRQLPLLN ALLIELSLLC NQPVASPTQV HPHLAWLYRG EDKGPDPSTK STSPSESKSN
KLSVRENEKL VNPQSKKNPK GKHPKIGGSP PPKVTKGRLL YGLTNTLRLR LQQTNPNMLV
VHEKREQYRR SQIQAVGPKL RIPSWKGKVS SSAAESQMSP QLPADTPTDS NGKLPSLAVQ
SQLPPQLPGD ESLDSIGSFE EGSDTSMQIR AGFDESSTTK EVKQSHAMKQ EMVDQSENRT
IVTALRAPVS PAGSVTPERS LRSNSFGGNW KNKVPSPGLS LQEPTVDKTV DEGKDGRQVK
AISAADTSEN RPTSRKSSCE SISELLYRDG FTSPCYSEDF CTTENNSRSL PAPDSSTGVE
HVQKGSRASK SSEARLSTRK NSSDSSSVLT PPFSAGSPVC SHKRSRALKI HDSLEEASSL
STSDFSSQWT NEKENQADPG SSKVMRKGRD SSTKLKVRAG HKSSEKSQSP RTSQVSSYEP
SNLSELELKA IDDSDLADFQ EEEDGLGSLR ISRQCKDICE LVINKLPGYT V
