MAP10_RAT
ID MAP10_RAT Reviewed; 888 AA.
AC D3ZAP3;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Microtubule-associated protein 10;
DE AltName: Full=Microtubule regulator of 120 KDa;
GN Name=Map10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-associated protein (MAP) that plays a role in the
CC regulation of cell division; promotes microtubule stability and
CC participates in the organization of the spindle midzone and normal
CC progress of cytokinesis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via middle region) with microtubules.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome {ECO:0000250}. Midbody
CC {ECO:0000250}. Note=Localized at stabilized microtubules (MTs) during
CC interphase and to the mitotic apparatus during mitosis. Localized at
CC spindle poles in metaphase and spindle midzone during telophase.
CC Colocalized with Polo-like kinase PLK1 to the center of spindle
CC midzone. Localized at the midbody during cytokinesis. Colocalized with
CC acetylated-tubulin at MTs (By similarity). {ECO:0000250}.
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DR EMBL; CH474054; EDL96759.1; -; Genomic_DNA.
DR RefSeq; NP_001264320.1; NM_001277391.1.
DR AlphaFoldDB; D3ZAP3; -.
DR STRING; 10116.ENSRNOP00000036118; -.
DR PhosphoSitePlus; D3ZAP3; -.
DR PaxDb; D3ZAP3; -.
DR PRIDE; D3ZAP3; -.
DR Ensembl; ENSRNOT00000031717; ENSRNOP00000036118; ENSRNOG00000028652.
DR GeneID; 307948; -.
DR KEGG; rno:307948; -.
DR CTD; 54627; -.
DR RGD; 1308644; Map10.
DR eggNOG; ENOG502QVBX; Eukaryota.
DR GeneTree; ENSGT00390000008459; -.
DR HOGENOM; CLU_014844_0_0_1; -.
DR InParanoid; D3ZAP3; -.
DR OMA; MLVVHEK; -.
DR OrthoDB; 486802at2759; -.
DR PhylomeDB; D3ZAP3; -.
DR TreeFam; TF338644; -.
DR PRO; PR:D3ZAP3; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Proteomes; UP000234681; Chromosome 19.
DR Bgee; ENSRNOG00000028652; Expressed in testis and 17 other tissues.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:1990023; C:mitotic spindle midzone; ISS:UniProtKB.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:UniProtKB.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; ISS:UniProtKB.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
DR GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
DR InterPro; IPR039302; MAP10.
DR InterPro; IPR026679; MAP10_C-term.
DR PANTHER; PTHR21831; PTHR21831; 1.
DR Pfam; PF14925; HPHLAWLY; 2.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..888
FT /note="Microtubule-associated protein 10"
FT /id="PRO_0000403448"
FT REGION 398..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 96280 MW; A76D3686919D67A2 CRC64;
MAATAAERLF SLELLVDWVR LDSPCFASPA VAFRLLDFPP LLILPPAAPD PEPQRGAITF
GRGKACLLRL RPAALRRPRL RAALLQLPAV PTPAPLLLGA CDILLVPSVG QRGIFTLRGP
EAERVGELAL FYRLTDLGRF PPGAPQLRSP LSPACITGSE ALEVSEPRTK ETSKPCTKDT
SARCLQCVSN GRFLEAPEPC AKDTDNWSAG DSDASAVQKS WEEAILHSKA SSGDMASAPC
SPAPSGRTVS PVSLEVTELD FETNTFCPPP LYYTHLTQEK APSARVEITI EPQRNEPEDL
EDAFPETKPV GPTIRPVKHT RAAIQESPPV LLNLPQMQGP GEANEAPCPP QTEQSTVGAI
RQLPLLNALL MELSLLCNQP VANPSQVHPH LAWLYRGEHK GPDPSTKSTS RSESKSNKLS
AQENEKLVSP QSTKNPKGKH SKISGSPPPK VTKGRLLYGL TNTLRLRLQQ TNPGMLVVHE
KREQYRRSQI RAVGPKFRIP SWKGKVSSLA AESQMPPQLP GDTLTDSNGK VSSWAVQSQL
PPQLPRDRSL DSYGSFAEGS DTSMLISSGF DESSRTREAK QSHAMKKETV GQSENKTVTS
LRAPVSPAVS VIPERSPRSN ILRGKWKKQV QSPGLSRQDP AVDKAVGEGI DGKQVKAASA
ADTNENRPPS RKSSCESTSE LQCWDGSTSP CYSEDFCTTE NNSRSLPAPD SSTGAEYAQK
GSWASKSSEA RLSTRKNSSE SSSVFTPPFS AGSPVCSQKR SRVLKTHDSL EEASSLSTSD
FSSQWTNEKE NQADPGSSKI RRRQDRSTKL KVGTGHKSSE KSHSARTSQV SSYEPSNLSE
LELKAIDDID SASTGFQEEE DGLGSLRISR QCRDICELVI NKLPGYTV
