MAP11_CAEEL
ID MAP11_CAEEL Reviewed; 878 AA.
AC P91859; H2FLK1; Q7YXB8; Q7YXB9;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Microtubule-associated protein homolog maph-1.1 {ECO:0000312|WormBase:F32A7.5a};
GN Name=maph-1.1 {ECO:0000303|PubMed:27506200, ECO:0000312|WormBase:F32A7.5a};
GN ORFNames=F32A7.5 {ECO:0000312|WormBase:F32A7.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP INTERACTION WITH DLG-1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=27506200; DOI=10.1186/s12915-016-0286-x;
RA Waaijers S., Munoz J., Berends C., Ramalho J.J., Goerdayal S.S., Low T.Y.,
RA Zoumaro-Djayoon A.D., Hoffmann M., Koorman T., Tas R.P., Harterink M.,
RA Seelk S., Kerver J., Hoogenraad C.C., Bossinger O., Tursun B.,
RA van den Heuvel S., Heck A.J., Boxem M.;
RT "A tissue-specific protein purification approach in Caenorhabditis elegans
RT identifies novel interaction partners of DLG-1/Discs large.";
RL BMC Biol. 14:66-66(2016).
CC -!- SUBUNIT: Interacts with dlg-1. {ECO:0000269|PubMed:27506200}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000269|PubMed:27506200}. Perikaryon
CC {ECO:0000269|PubMed:27506200}. Cell projection, axon
CC {ECO:0000269|PubMed:27506200}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:27506200}. Note=Localizes to microtubules in the
CC neuronal cell body, axon and dendrites. {ECO:0000269|PubMed:27506200}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=a {ECO:0000312|WormBase:F32A7.5a};
CC IsoId=P91859-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F32A7.5b};
CC IsoId=P91859-2; Sequence=VSP_058990, VSP_058991;
CC Name=c {ECO:0000312|WormBase:F32A7.5c};
CC IsoId=P91859-3; Sequence=VSP_058992;
CC Name=d {ECO:0000312|WormBase:F32A7.5d};
CC IsoId=P91859-4; Sequence=VSP_058989;
CC -!- DEVELOPMENTAL STAGE: Expressed in somatic tissues including neurons,
CC body wall muscle cells, the vulva, vulval muscle cells, the hypodermis,
CC seam cells, and intestinal cells at the L4 stage of larval development.
CC {ECO:0000269|PubMed:27506200}.
CC -!- SIMILARITY: Belongs to the MAP1A/MAP1B/MAP1S family. {ECO:0000305}.
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DR EMBL; BX284601; CAB05498.1; -; Genomic_DNA.
DR EMBL; BX284601; CAD92390.1; -; Genomic_DNA.
DR EMBL; BX284601; CAD92391.1; -; Genomic_DNA.
DR EMBL; BX284601; CCF23322.1; -; Genomic_DNA.
DR PIR; T21621; T21621.
DR RefSeq; NP_001021436.1; NM_001026265.2. [P91859-1]
DR RefSeq; NP_001021437.1; NM_001026266.2. [P91859-2]
DR RefSeq; NP_001021438.1; NM_001026267.2. [P91859-3]
DR RefSeq; NP_001252456.1; NM_001265527.1. [P91859-4]
DR AlphaFoldDB; P91859; -.
DR STRING; 6239.F32A7.5a; -.
DR EPD; P91859; -.
DR PaxDb; P91859; -.
DR PeptideAtlas; P91859; -.
DR EnsemblMetazoa; F32A7.5a.1; F32A7.5a.1; WBGene00009306. [P91859-1]
DR EnsemblMetazoa; F32A7.5b.1; F32A7.5b.1; WBGene00009306. [P91859-2]
DR EnsemblMetazoa; F32A7.5c.1; F32A7.5c.1; WBGene00009306. [P91859-3]
DR EnsemblMetazoa; F32A7.5d.1; F32A7.5d.1; WBGene00009306. [P91859-4]
DR GeneID; 173357; -.
DR KEGG; cel:CELE_F32A7.5; -.
DR UCSC; F32A7.5c; c. elegans.
DR CTD; 173357; -.
DR WormBase; F32A7.5a; CE09846; WBGene00009306; maph-1.1. [P91859-1]
DR WormBase; F32A7.5b; CE34178; WBGene00009306; maph-1.1. [P91859-2]
DR WormBase; F32A7.5c; CE34179; WBGene00009306; maph-1.1. [P91859-3]
DR WormBase; F32A7.5d; CE47031; WBGene00009306; maph-1.1. [P91859-4]
DR eggNOG; KOG3592; Eukaryota.
DR GeneTree; ENSGT00970000196160; -.
DR InParanoid; P91859; -.
DR OMA; PLYFDIV; -.
DR OrthoDB; 86642at2759; -.
DR PhylomeDB; P91859; -.
DR PRO; PR:P91859; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00009306; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005875; C:microtubule associated complex; IBA:GO_Central.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:WormBase.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0031114; P:regulation of microtubule depolymerization; IBA:GO_Central.
DR InterPro; IPR026074; MAP1.
DR PANTHER; PTHR13843; PTHR13843; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..878
FT /note="Microtubule-associated protein homolog maph-1.1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000440782"
FT REGION 224..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 381..439
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058989"
FT VAR_SEQ 440..567
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058990"
FT VAR_SEQ 816
FT /note="D -> DSGKFENSFDLINYF (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058991"
FT VAR_SEQ 817..818
FT /note="SA -> T (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_058992"
SQ SEQUENCE 878 AA; 92238 MW; E7AF7851A88CCC0E CRC64;
MPEEYIMSSK ACIYVLGGAA NTAALFDFDG VYILDGGFAE KNPGFVAHVR DVSAVLLAAP
TLGNLGTTSA LLEQGKPLPV FTNTKPFKTA KPGSSGEIAK AIQEANSKIL SVAPPLFNPK
YPANIIYQSA AKGVLSLYIL AGDVKDAEVI TKALAGGNEA EVEKAAAEHG TIGVLLWRPA
MTDQSVVRVL ISGTSSLSRI QQSLDKAAKS LPFLNVPTVK SKDALSDIPA PAVPRPVAGK
PSARPATTTG TATRPTRPAV PAASAPRALT SRAPAGPSRP TTTRNAAPAP RTAVPSRATV
LTKTAPASKA PTRAPVPARS APAPPRGAPA KPAANTAKAE PIAQKKTVGK VQGTAPSKPA
PAAPASAATS PAPAPEAPRR DPNNVTIVLD DSLSPEDFNQ GSAPMDIVVI PPTPEPPRHE
VAQATHPEES IIDAEDLAKA PLEVDDVANL ADVEDEIPPP VDAFKKPEPH PEPNVSGGSE
EDKIPEPVDA FKKPDPVELD DFDPLKPSHP EPSAPVVPSD HIIIATPDPE LPDIVAAVPF
VSPSPKGPND GLVKLDDELE KIAPGFEEPL IPQAPRDDGT LAECSEEVSK LVEISMDTDN
SAEVAADLAK AVGEVTQLSA DLQNLGLDEK TDEYVRKLSN QMIEDATLPF TSALASSIVT
SNGSETNGHG EQAHAAQNGG IDHQKEIPKH DLMQSRSSVI ENGAAVQYEK TDPALDDVLN
ACAQESEKID ASHPDNLHMP AAPGSAAPAK PVKFARPYYF DVVTVPRNEK LETSVAADGL
QEFISKVRSR NVILASKDIS GEQLQAILCG KQTWCDSAHP CNVIPTHSSP MLLDFRQKNE
EQFAANNLQF SIPVEKQRTT VSSDAGAIEY ELARVDLL
