MAP3_SCHPO
ID MAP3_SCHPO Reviewed; 365 AA.
AC P31397;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Pheromone M-factor receptor;
GN Name=map3; ORFNames=SPAC3F10.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ST711;
RX PubMed=8380233; DOI=10.1128/mcb.13.1.80-88.1993;
RA Tanaka K., Davey J., Imai Y., Yamamoto M.;
RT "Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.";
RL Mol. Cell. Biol. 13:80-88(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Receptor for the peptide pheromone M-factor, a mating factor
CC of S.pombe. Pheromone signaling is essential for initiation of meiosis
CC in S.pombe; M-factor signaling alone may be sufficient.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By at least 3 types of regulation: the mating-type of the
CC cell, nutritional conditions and pheromone signaling.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 4 family.
CC {ECO:0000305}.
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DR EMBL; D10933; BAA01727.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA93308.1; -; Genomic_DNA.
DR PIR; A48105; A48105.
DR RefSeq; NP_593942.1; NM_001019370.2.
DR AlphaFoldDB; P31397; -.
DR SMR; P31397; -.
DR BioGRID; 278740; 8.
DR STRING; 4896.SPAC3F10.10c.1; -.
DR iPTMnet; P31397; -.
DR PaxDb; P31397; -.
DR PRIDE; P31397; -.
DR EnsemblFungi; SPAC3F10.10c.1; SPAC3F10.10c.1:pep; SPAC3F10.10c.
DR PomBase; SPAC3F10.10c; map3.
DR VEuPathDB; FungiDB:SPAC3F10.10c; -.
DR eggNOG; ENOG502S44N; Eukaryota.
DR HOGENOM; CLU_763245_0_0_1; -.
DR InParanoid; P31397; -.
DR OMA; WHQESIT; -.
DR PhylomeDB; P31397; -.
DR PRO; PR:P31397; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0031520; C:plasma membrane of cell tip; IDA:PomBase.
DR GO; GO:0004932; F:mating-type factor pheromone receptor activity; EXP:PomBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IC:PomBase.
DR GO; GO:0071507; P:pheromone response MAPK cascade; IMP:PomBase.
DR GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IBA:GO_Central.
DR GO; GO:0051446; P:positive regulation of meiotic cell cycle; IC:PomBase.
DR InterPro; IPR001499; GPCR_STE3.
DR PANTHER; PTHR28097; PTHR28097; 1.
DR Pfam; PF02076; STE3; 1.
DR PRINTS; PR00899; GPCRSTE3.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Membrane; Pheromone response; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..365
FT /note="Pheromone M-factor receptor"
FT /id="PRO_0000195075"
FT TRANSMEM 7..24
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..54
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..100
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..133
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..182
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..226
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 365 AA; 42498 MW; 306A022FA7DCFEF7 CRC64;
MLPIGIFYQF YAYFALVLSI PILYMQLRAR NIPCLLLLFW LTLTTLIYVV ESAIWSNPYA
ETIRWMGYGL CDITSRIVTC SSIGIPASAF TLVLYLDTVI RRDHPLKRYE NWIWHVCLSI
LLPLIIMAMM VPLESNRYVV ICMNGCYSSF YQTWYTLLFF YIPPCLLSFG GLFFVSRIVV
LYWRRQRELQ QFFQRDSQLT SKRFLRLLCL AAVFFLGYFP LTIFMVVANG KLQQFLPFNH
ELVEAWHQES ITYYPTTKVG LNDWVPPTVL YLMSLFFSTS GGWTEKVALI LWSLLVWLPF
TKNTALGRHA QFKLDCCKSI ESTMAGKTLD STDFKEKCLV LERQWSKSSI PSDNSSELQD
AAKYV
