ID   MAP6_CHICK              Reviewed;         369 AA.
AC   O73737;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Microtubule-associated protein 6 homolog;
DE            Short=MAP-6 homolog;
DE   AltName: Full=Stable tubule-only polypeptide homolog;
DE            Short=STOP;
GN   Name=MAP6; Synonyms=Nau;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11186198;
RA   Suzuki M., Takagi M., Takeda S., Katsube K.;
RT   "Molecular cloning of the chick Nau gene and analysis of its expression
RT   patterns during neurogenesis.";
RL   J. Med. Dent. Sci. 45:123-133(1998).
CC   -!- FUNCTION: Involved in microtubule stabilization in many cell types,
CC       including neuronal cells. Specifically has microtubule cold stabilizing
CC       activity. Involved in dendrite morphogenesis and maintenance by
CC       regulating lysosomal trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: In the embryo is expressed in the developing
CC       hindbrain and is accumulated in rhombomere boundary regions and in the
CC       rhombomere 2, 4 and 6. {ECO:0000269|PubMed:11186198}.
CC   -!- SIMILARITY: Belongs to the STOP family. {ECO:0000305}.
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DR   EMBL; AF038560; AAC79958.1; -; mRNA.
DR   RefSeq; NP_990250.1; NM_204919.1.
DR   AlphaFoldDB; O73737; -.
DR   STRING; 9031.ENSGALP00000012027; -.
DR   PRIDE; O73737; -.
DR   GeneID; 395753; -.
DR   KEGG; gga:395753; -.
DR   CTD; 4135; -.
DR   VEuPathDB; HostDB:geneid_395753; -.
DR   eggNOG; ENOG502QS1F; Eukaryota.
DR   InParanoid; O73737; -.
DR   OrthoDB; 1148443at2759; -.
DR   PhylomeDB; O73737; -.
DR   PRO; PR:O73737; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR007882; MAP6.
DR   PANTHER; PTHR14759; PTHR14759; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Transport.
FT   CHAIN           1..369
FT                   /note="Microtubule-associated protein 6 homolog"
FT                   /id="PRO_0000344047"
FT   REGION          41..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..110
FT                   /note="Mn 1"
FT   REGION          122..145
FT                   /note="Mn 2"
FT   REGION          228..251
FT                   /note="Mn 3"
FT   REGION          251..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  40820 MW;  641B6A04760F58AD CRC64;
     MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEQP LPAQIPRSAA APIDTQPGGD
     ARAAGGGDAA PGPARPGTAP HGSPPADSVM RHDYKPWKVQ RPEPSCKPKS EYQPSDTPFE
     KETQYQKDFR AWPIPKRGDH PWIPKAGPSP VLGPERGSPE KAAQEKRRKK EEEAEADEEH
     PKAARPGDAR EKGRQRGDEA GGQEGRGRAA ADALNRQIKE EVVAAGVSSS YRNEFRPWID
     VKPVKAIKAK AQYKPPEEKM THETSYSAQF KGETSKPAPA DNKFLERRRI RTLYSEPYKE
     PPKVEKPSVK PSKPKKTTTS HKPLKKAKDK QIASGRAAKK KSAETSNTAK PEDKEKSKEM
     NNKLAEAKE