ID   MAP6_XENTR              Reviewed;         378 AA.
AC   B0S4Q5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Microtubule-associated protein 6 homolog;
DE            Short=MAP-6 homolog;
DE   AltName: Full=Stable tubule-only polypeptide homolog;
DE            Short=STOP;
GN   Name=map6;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in microtubule stabilization in many cell types,
CC       including neuronal cells. Specifically has microtubule cold stabilizing
CC       activity. Involved in dendrite morphogenesis and maintenance by
CC       regulating lysosomal trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STOP family. {ECO:0000305}.
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DR   EMBL; BC159130; AAI59131.1; -; mRNA.
DR   RefSeq; NP_001120222.1; NM_001126750.1.
DR   AlphaFoldDB; B0S4Q5; -.
DR   PRIDE; B0S4Q5; -.
DR   Ensembl; ENSXETT00000032960; ENSXETP00000032960; ENSXETG00000015061.
DR   InParanoid; B0S4Q5; -.
DR   OMA; TTTGKMV; -.
DR   OrthoDB; 1148443at2759; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015061; Expressed in brain and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR007882; MAP6.
DR   PANTHER; PTHR14759; PTHR14759; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Transport.
FT   CHAIN           1..378
FT                   /note="Microtubule-associated protein 6 homolog"
FT                   /id="PRO_0000344048"
FT   REGION          36..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..99
FT                   /note="Mn 1"
FT   REGION          112..135
FT                   /note="Mn 2"
FT   REGION          203..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          237..260
FT                   /note="Mn 3"
FT   COMPBIAS        203..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  42018 MW;  698F7765B402560A CRC64;
     MAWPCVTRAC CIARFGNLQD KGDIAVPLMY SKYSEVTDGA QPPPPRPGSA AIETQPSLSD
     PYSGSLGRFS KKPESARGSV MRQDYQAWKA NPEPSCKPRI EYQPSEAPLE RETQYKKDFR
     SWPIPRQGDH PWIPKLSPSP TMPVIASDDK RKKDFVAPKA PPAEIKLINA EQPESAKGRG
     PTAFIAAPEI LISVVQETNE IQKRESFMPK LPAKEPRATR DTGSPHPAQA RGERGAGTSY
     RNEFRPWTDV KPVKPIKAKS QYQPPEEKVV HETSYKATFK GESNQPAAGD NKLMERRRIR
     SLYSEPSKES SKVEKPSVQT SKPKKTSTSH KPVKKAKEKI MASGRASKKK GAESSSTTKP
     EEKEKSKEIN NKLAEAKE