ID   MAP_STAAR               Reviewed;         689 AA.
AC   Q6GFB8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein map;
DE   AltName: Full=MHC class II analog protein;
DE   Flags: Precursor;
GN   Name=map; OrderedLocusNames=SAR2030;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Both native and recombinant protein bound to labeled
CC       vitronectin, fibrinogen, recombinant osteopontin and fibronectin. It
CC       was also shown to be able to bind to a 15-amino acid synthetic peptide
CC       of vitronectin. Map could affect the severity of arthritis and
CC       osteomyelitis in mice through a T-cell-mediated mechanism and could
CC       play a role in abscess formation through a T-cell-independent
CC       mechanisms. It could potentiate the survival of the bacterium by
CC       modulating host immunity (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: Each MAP domain contains a 31-residue subdomain that shares
CC       striking sequence homology with a segment present in the peptide
CC       binding groove of the beta chain of the MHC class II proteins from
CC       different mammalian species.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571856; CAG41016.1; -; Genomic_DNA.
DR   RefSeq; WP_000669729.1; NC_002952.2.
DR   AlphaFoldDB; Q6GFB8; -.
DR   SMR; Q6GFB8; -.
DR   KEGG; sar:SAR2030; -.
DR   HOGENOM; CLU_351921_0_0_9; -.
DR   OMA; HHGYSKI; -.
DR   OrthoDB; 2105421at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   InterPro; IPR005298; MAP_dom.
DR   Pfam; PF03642; MAP; 6.
DR   PROSITE; PS51223; MAP; 6.
PE   3: Inferred from homology;
KW   Repeat; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000250"
FT   CHAIN           31..689
FT                   /note="Protein map"
FT                   /id="PRO_0000227540"
FT   REPEAT          45..154
FT                   /note="MAP 1"
FT   REPEAT          155..264
FT                   /note="MAP 2"
FT   REPEAT          265..374
FT                   /note="MAP 3"
FT   REPEAT          375..474
FT                   /note="MAP 4"
FT   REPEAT          475..584
FT                   /note="MAP 5"
FT   REPEAT          588..689
FT                   /note="MAP 6"
SQ   SEQUENCE   689 AA;  76848 MW;  4141D8900549099D CRC64;
     MKFKSLITTT LALGVLASTG ANFNTNEASA AAKQIDKSSS SLHHGYSKIQ IPYTITVNGT
     SQNILSSLTF NKNQQISYKD IENKVKSVLY FNRGISDIDL RLSKQAKYTV HFKNGTKRVV
     DLKAGIHTAD LINTSDIKAI SVNVDTKKQV KDKEAKANVQ VPYTITVNGT SQNILSNLTF
     KKNQQISYKD LENNVKSVLK SNRGITDVDL RLSKQAKFTV NFKNGTKKVI DLKAGIYTAN
     LINTGDIKNI NINVETKKQA KDKEAKANNQ VPYSINLNGT TTNIQSNLAF SNKPWTNYKN
     LTAKVKSVLK SDRGVSERDL KHAKKAYYTV YFKNGGKRVI HLNSNIYTAN LVHAKDIKKI
     EVTVKTGSKA NAERYVPYTI AVNGTSTPNL SDLKFKGDSR VSYSDITKKV KSVLKYDRGI
     GERELKYAKK ATYTVHFKNG TKKVINLNSK ISQLNLLFVK DIKKIDVDVK TGSKAKADSY
     VPYTIAVNGT STPIASKLKL SNKQLIGYQD LNKKVKSVLK HDRGINDIEL KFAKQAKYTV
     HFKNGKTQVV DLKSDIFTRN LFSVKDIKKI DIDVKQHTKS NKALNKVSNI ATKVKFPVTI
     NGFSNVVSNE FAFLHPHKIT TNDLNAKLRL ALASDQGITK HDIGLSERTV YKVYFKDGSS
     KFVDLKAAKQ DSKVFKATDI KKVDIEIKF