ID   MARA_ECO57              Reviewed;         127 AA.
AC   P0ACH6; P27246;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Multiple antibiotic resistance protein MarA;
GN   Name=marA; OrderedLocusNames=Z2170, ECs2138;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: May be a transcriptional activator of genes involved in the
CC       multiple antibiotic resistance (Mar) phenotype. It can also activate
CC       genes such as sodA, zwf and micF (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG56233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB35561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG56233.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB35561.1; ALT_INIT; Genomic_DNA.
DR   PIR; B90896; B90896.
DR   PIR; E85721; E85721.
DR   RefSeq; NP_310165.2; NC_002695.1.
DR   RefSeq; WP_000091199.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACH6; -.
DR   SMR; P0ACH6; -.
DR   STRING; 155864.EDL933_2106; -.
DR   EnsemblBacteria; AAG56233; AAG56233; Z2170.
DR   EnsemblBacteria; BAB35561; BAB35561; ECs_2138.
DR   GeneID; 66674615; -.
DR   GeneID; 917339; -.
DR   KEGG; ece:Z2170; -.
DR   KEGG; ecs:ECs_2138; -.
DR   PATRIC; fig|386585.9.peg.2245; -.
DR   eggNOG; COG4977; Bacteria.
DR   HOGENOM; CLU_000445_81_14_6; -.
DR   OMA; FKKHFNT; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic resistance; DNA-binding; Reference proteome; Repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..127
FT                   /note="Multiple antibiotic resistance protein MarA"
FT                   /id="PRO_0000194532"
FT   DOMAIN          12..110
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        29..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        77..100
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   127 AA;  15184 MW;  A547C8F1553A9196 CRC64;
     MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
     RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRMT NMQGESRFLH
     PLNHYNS