ID   MARA_SALEN              Reviewed;         127 AA.
AC   P0A2S6; Q56070;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Multiple antibiotic resistance protein MarA;
GN   Name=marA;
OS   Salmonella enteritidis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=149539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10856650; DOI=10.1111/j.1574-6968.2000.tb09153.x;
RA   Kunonga N.I., Sobieski R.J., Crupper S.S.;
RT   "Prevalence of the multiple antibiotic resistance operon (marRAB) in the
RT   genus Salmonella.";
RL   FEMS Microbiol. Lett. 187:155-160(2000).
CC   -!- FUNCTION: May be a transcriptional activator of genes involved in the
CC       multiple antibiotic resistance (Mar) phenotype. It can also activate
CC       genes such as sodA, zwf and micF.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF61916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF226275; AAF61916.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000091194.1; NZ_WIAP01000025.1.
DR   AlphaFoldDB; P0A2S6; -.
DR   SMR; P0A2S6; -.
DR   PATRIC; fig|149539.316.peg.1655; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic resistance; DNA-binding; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..127
FT                   /note="Multiple antibiotic resistance protein MarA"
FT                   /id="PRO_0000194533"
FT   DOMAIN          12..110
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        29..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        77..100
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   127 AA;  15155 MW;  1EFA7FBC953A8EAD CRC64;
     MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
     RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRIT NMHGESRYML
     PLNHGNY