ID   MARA_SALTI              Reviewed;         127 AA.
AC   P0A2S5; Q56070;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Multiple antibiotic resistance protein MarA;
GN   Name=marA; OrderedLocusNames=STY1541, t1440;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: May be a transcriptional activator of genes involved in the
CC       multiple antibiotic resistance (Mar) phenotype. It can also activate
CC       genes such as sodA, zwf and micF (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL513382; CAD01794.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69082.1; -; Genomic_DNA.
DR   PIR; AI0677; AI0677.
DR   RefSeq; NP_455961.3; NC_003198.1.
DR   RefSeq; WP_000091194.1; NZ_WSUR01000006.1.
DR   AlphaFoldDB; P0A2S5; -.
DR   SMR; P0A2S5; -.
DR   STRING; 220341.16502639; -.
DR   EnsemblBacteria; AAO69082; AAO69082; t1440.
DR   KEGG; stt:t1440; -.
DR   KEGG; sty:STY1541; -.
DR   PATRIC; fig|220341.7.peg.1550; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_000445_81_14_6; -.
DR   OMA; FKKHFNT; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic resistance; DNA-binding; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..127
FT                   /note="Multiple antibiotic resistance protein MarA"
FT                   /id="PRO_0000194534"
FT   DOMAIN          12..110
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        29..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        77..100
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   127 AA;  15155 MW;  1EFA7FBC953A8EAD CRC64;
     MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
     RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRIT NMHGESRYML
     PLNHGNY