MARA_SALTY
ID MARA_SALTY Reviewed; 127 AA.
AC P0A2S4; Q56070;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Multiple antibiotic resistance protein MarA;
GN Name=marA; OrderedLocusNames=STM1519;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=X3181;
RX PubMed=9068629; DOI=10.1128/jb.179.6.1857-1866.1997;
RA Sulavik M.C., Dazer M., Miller P.F.;
RT "The Salmonella typhimurium mar locus: molecular and genetic analyses and
RT assessment of its role in virulence.";
RL J. Bacteriol. 179:1857-1866(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: May be a transcriptional activator of genes involved in the
CC multiple antibiotic resistance (Mar) phenotype. It can also activate
CC genes such as sodA, zwf and micF.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC44977.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL20438.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U54468; AAC44977.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006468; AAL20438.1; ALT_INIT; Genomic_DNA.
DR PIR; T11757; T11757.
DR RefSeq; NP_460479.4; NC_003197.2.
DR AlphaFoldDB; P0A2S4; -.
DR SMR; P0A2S4; -.
DR STRING; 99287.STM1519; -.
DR PaxDb; P0A2S4; -.
DR EnsemblBacteria; AAL20438; AAL20438; STM1519.
DR GeneID; 1253037; -.
DR KEGG; stm:STM1519; -.
DR PATRIC; fig|99287.12.peg.1607; -.
DR HOGENOM; CLU_000445_81_14_6; -.
DR OMA; FKKHFNT; -.
DR PhylomeDB; P0A2S4; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; Antibiotic resistance; DNA-binding; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..127
FT /note="Multiple antibiotic resistance protein MarA"
FT /id="PRO_0000194535"
FT DOMAIN 12..110
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 29..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 77..100
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 127 AA; 15155 MW; 1EFA7FBC953A8EAD CRC64;
MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRIT NMHGESRYML
PLNHGNY
