MARA_SHIFL
ID MARA_SHIFL Reviewed; 127 AA.
AC P0ACH7; P27246;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Multiple antibiotic resistance protein MarA;
GN Name=marA; OrderedLocusNames=SF1563, S1690;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: May be a transcriptional activator of genes involved in the
CC multiple antibiotic resistance (Mar) phenotype. It can also activate
CC genes such as sodA, zwf and micF (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
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DR EMBL; AE005674; AAN43152.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP17046.1; -; Genomic_DNA.
DR RefSeq; NP_707445.2; NC_004337.2.
DR RefSeq; WP_000091199.1; NZ_WPGW01000096.1.
DR AlphaFoldDB; P0ACH7; -.
DR SMR; P0ACH7; -.
DR STRING; 198214.SF1563; -.
DR EnsemblBacteria; AAN43152; AAN43152; SF1563.
DR EnsemblBacteria; AAP17046; AAP17046; S1690.
DR GeneID; 1026416; -.
DR GeneID; 66674615; -.
DR KEGG; sfl:SF1563; -.
DR KEGG; sfx:S1690; -.
DR PATRIC; fig|198214.7.peg.1848; -.
DR HOGENOM; CLU_000445_81_14_6; -.
DR OrthoDB; 1748122at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; Antibiotic resistance; DNA-binding; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..127
FT /note="Multiple antibiotic resistance protein MarA"
FT /id="PRO_0000194536"
FT DOMAIN 12..110
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 29..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 77..100
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 127 AA; 15184 MW; A547C8F1553A9196 CRC64;
MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRMT NMQGESRFLH
PLNHYNS
