MARC_ECOLI
ID MARC_ECOLI Reviewed; 221 AA.
AC P0AEY1; P31123; P31124; P77753;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=UPF0056 inner membrane protein MarC;
GN Name=marC; Synonyms=ydeB, ydeC; OrderedLocusNames=b1529, JW1522;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8383113; DOI=10.1128/jb.175.5.1484-1492.1993;
RA Cohen S.P., Haechler H., Levy S.B.;
RT "Genetic and functional analysis of the multiple antibiotic resistance
RT (mar) locus in Escherichia coli.";
RL J. Bacteriol. 175:1484-1492(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP GENE NAME.
RA Haechler H.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TOPOLOGY.
RC STRAIN=K12 / JM109 / ATCC 53323;
RX PubMed=11867724; DOI=10.1073/pnas.052018199;
RA Drew D., Sjoestrand D., Nilsson J., Urbig T., Chin C.-N., de Gier J.-W.,
RA von Heijne G.;
RT "Rapid topology mapping of Escherichia coli inner-membrane proteins by
RT prediction and PhoA/GFP fusion analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2690-2695(2002).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [8]
RP LACK OF INVOLVEMENT IN ANTIBIOTIC RESISTANCE.
RX PubMed=17954692; DOI=10.1128/aac.00930-07;
RA McDermott P.F., McMurry L.M., Podglajen I., Dzink-Fox J.L., Schneiders T.,
RA Draper M.P., Levy S.B.;
RT "The marC gene of Escherichia coli is not involved in multiple antibiotic
RT resistance.";
RL Antimicrob. Agents Chemother. 52:382-383(2008).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the UPF0056 (MarC) family. {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be involved in multiple antibiotic
CC resistance. {ECO:0000305|PubMed:8383113}.
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DR EMBL; M96235; AAC16396.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74602.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15211.2; -; Genomic_DNA.
DR PIR; D64907; D64907.
DR RefSeq; NP_416046.1; NC_000913.3.
DR RefSeq; WP_000885033.1; NZ_STEB01000003.1.
DR AlphaFoldDB; P0AEY1; -.
DR BioGRID; 4259109; 12.
DR STRING; 511145.b1529; -.
DR TCDB; 2.A.95.1.1; the 6 tms neutral amino acid transporter (naat) family.
DR PaxDb; P0AEY1; -.
DR PRIDE; P0AEY1; -.
DR EnsemblBacteria; AAC74602; AAC74602; b1529.
DR EnsemblBacteria; BAA15211; BAA15211; BAA15211.
DR GeneID; 66674617; -.
DR GeneID; 947132; -.
DR KEGG; ecj:JW1522; -.
DR KEGG; eco:b1529; -.
DR PATRIC; fig|1411691.4.peg.737; -.
DR EchoBASE; EB1593; -.
DR eggNOG; COG2095; Bacteria.
DR HOGENOM; CLU_079909_2_0_6; -.
DR InParanoid; P0AEY1; -.
DR OMA; MMAIVML; -.
DR PhylomeDB; P0AEY1; -.
DR BioCyc; EcoCyc:EG11637-MON; -.
DR PRO; PR:P0AEY1; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:EcoliWiki.
DR InterPro; IPR002771; Multi_antbiot-R_MarC.
DR PANTHER; PTHR33508; PTHR33508; 1.
DR Pfam; PF01914; MarC; 1.
DR TIGRFAMs; TIGR00427; TIGR00427; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..221
FT /note="UPF0056 inner membrane protein MarC"
FT /id="PRO_0000156897"
FT TOPO_DOM 1..7
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..68
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..154
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..221
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 221 AA; 23617 MW; 7957FF9403C5F135 CRC64;
MLDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMNSAER NRQSLMASVY VFAIMMVAYY
AGQLVMDTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAID SPEAKSKSEE LEDEPSANIA
FVPLAMPSTA GPGTIAMIIS SASTVRQSST FADWVLMVAP PLIFFLVAVI LWGSLRSSGA
IMRLVGKGGI EAISRLMGFL LVCMGVQFII NGILEIIKTY H
