ID   MARC_ECOUT              Reviewed;         221 AA.
AC   Q1RBN8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=UPF0056 inner membrane protein MarC;
GN   Name=marC; OrderedLocusNames=UTI89_C1748;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0056 (MarC) family. {ECO:0000305}.
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DR   EMBL; CP000243; ABE07226.1; -; Genomic_DNA.
DR   RefSeq; WP_000885042.1; NC_007946.1.
DR   AlphaFoldDB; Q1RBN8; -.
DR   EnsemblBacteria; ABE07226; ABE07226; UTI89_C1748.
DR   KEGG; eci:UTI89_C1748; -.
DR   HOGENOM; CLU_079909_2_0_6; -.
DR   OMA; MMAIVML; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002771; Multi_antbiot-R_MarC.
DR   PANTHER; PTHR33508; PTHR33508; 1.
DR   Pfam; PF01914; MarC; 1.
DR   TIGRFAMs; TIGR00427; TIGR00427; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="UPF0056 inner membrane protein MarC"
FT                   /id="PRO_0000343815"
FT   TOPO_DOM        1..7
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..44
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..68
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..118
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..154
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..196
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..221
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  23590 MW;  68AB1298E2391C35 CRC64;
     MLDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMSSAER NRQSLMASVY VFAIMMVAYY
     AGQLVMDTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAID SPEAKSKSEE LEDEPSANIA
     FVPLAMPSTA GPGTIAMIIS SASTVRQSST FADWVLMVAP PLIFFLVAVI LWGSLRSSGA
     IMRLVGKGGI EAISRLMGFL LVCMGVQFII NGILEIIKTY H