ID   MARC_SALTY              Reviewed;         221 AA.
AC   P0A2L5; Q56068;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=UPF0056 inner membrane protein MarC;
GN   Name=marC; OrderedLocusNames=STM1521;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=X3181;
RX   PubMed=9068629; DOI=10.1128/jb.179.6.1857-1866.1997;
RA   Sulavik M.C., Dazer M., Miller P.F.;
RT   "The Salmonella typhimurium mar locus: molecular and genetic analyses and
RT   assessment of its role in virulence.";
RL   J. Bacteriol. 179:1857-1866(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0056 (MarC) family. {ECO:0000305}.
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DR   EMBL; U54468; AAC44975.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20440.1; -; Genomic_DNA.
DR   PIR; T11755; T11755.
DR   RefSeq; NP_460481.1; NC_003197.2.
DR   RefSeq; WP_000968968.1; NC_003197.2.
DR   AlphaFoldDB; P0A2L5; -.
DR   STRING; 99287.STM1521; -.
DR   PaxDb; P0A2L5; -.
DR   EnsemblBacteria; AAL20440; AAL20440; STM1521.
DR   GeneID; 1253039; -.
DR   KEGG; stm:STM1521; -.
DR   PATRIC; fig|99287.12.peg.1609; -.
DR   HOGENOM; CLU_079909_2_0_6; -.
DR   OMA; MMAIVML; -.
DR   PhylomeDB; P0A2L5; -.
DR   BioCyc; SENT99287:STM1521-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   InterPro; IPR002771; Multi_antbiot-R_MarC.
DR   PANTHER; PTHR33508; PTHR33508; 1.
DR   Pfam; PF01914; MarC; 1.
DR   TIGRFAMs; TIGR00427; TIGR00427; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="UPF0056 inner membrane protein MarC"
FT                   /id="PRO_0000156899"
FT   TOPO_DOM        1..7
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..45
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..68
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..118
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..154
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..196
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..221
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  23607 MW;  3ACAAF7BE4497E4A CRC64;
     MMDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMNSAER NRQSYMASVY VFAIMMVAYY
     AGQLVMNTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAHE SPEAKSKSEE LADEPTANIA
     FVPLAMPSTA GPGTIAMIIS SASTVRHGGE FPDWVIMVAP PIIFLAVAVI LWGCLRSSGA
     IMRLVGKGGI EAISRLMGFL LVCMGVQFII NGVLEIIKTY H