MARF1_CHICK
ID MARF1_CHICK Reviewed; 1741 AA.
AC E1BZ85;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Meiosis regulator and mRNA stability factor 1 {ECO:0000250|UniProtKB:Q9Y4F3};
DE AltName: Full=Limkain-b1;
DE AltName: Full=Meiosis arrest female protein 1 homolog;
GN Name=MARF1 {ECO:0000250|UniProtKB:Q9Y4F3}; Synonyms=LKAP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Essential regulator of oogenesis required for female meiotic
CC progression to repress transposable elements and preventing their
CC mobilization, which is essential for the germline integrity.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
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DR EMBL; AADN02023593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02023594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02023595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E1BZ85; -.
DR SMR; E1BZ85; -.
DR STRING; 9031.ENSGALP00000010450; -.
DR PaxDb; E1BZ85; -.
DR PRIDE; E1BZ85; -.
DR VEuPathDB; HostDB:geneid_416595; -.
DR eggNOG; ENOG502QUYZ; Eukaryota.
DR InParanoid; E1BZ85; -.
DR PhylomeDB; E1BZ85; -.
DR TreeFam; TF329117; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:1905762; F:CCR4-NOT complex binding; IBA:GO_Central.
DR GO; GO:1903231; F:mRNA base-pairing post-transcriptional repressor activity; IBA:GO_Central.
DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0016441; P:post-transcriptional gene silencing; IBA:GO_Central.
DR CDD; cd12255; RRM1_LKAP; 1.
DR CDD; cd12256; RRM2_LKAP; 1.
DR Gene3D; 3.30.420.610; -; 6.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR024768; Marf1.
DR InterPro; IPR045602; MARF1_LOTUS.
DR InterPro; IPR034189; MARF1_RRM1.
DR InterPro; IPR034191; MARF1_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021139; NYN_MARF1.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14379; PTHR14379; 2.
DR Pfam; PF11608; Limkain-b1; 1.
DR Pfam; PF19687; MARF1_LOTUS; 1.
DR Pfam; PF01936; NYN; 1.
DR Pfam; PF12872; OST-HTH; 5.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS51644; HTH_OST; 8.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Differentiation; Meiosis; Oogenesis; Peroxisome; Reference proteome;
KW Repeat; RNA-binding.
FT CHAIN 1..1741
FT /note="Meiosis regulator and mRNA stability factor 1"
FT /id="PRO_0000417528"
FT DOMAIN 345..482
FT /note="NYN"
FT DOMAIN 788..867
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 872..946
FT /note="HTH OST-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1000..1076
FT /note="HTH OST-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1097..1171
FT /note="HTH OST-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1173..1248
FT /note="HTH OST-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1257..1332
FT /note="HTH OST-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1333..1408
FT /note="HTH OST-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1409..1483
FT /note="HTH OST-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 1484..1558
FT /note="HTH OST-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT REGION 594..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1741 AA; 193326 MW; 76523AC7FCDB258E CRC64;
MEGNRTENLC NRSFGWLQRQ ENDVKPWLWK LSNCFSAAEK TLPCSAKTKD YMENQKGVVE
SKDASSHNAG SKLFPAVPLP DVHPLQQQQI QLSPGPKVSC CAHGSDSCTP QMHCGVGDGS
VIHPGTILDS KSTGTITCQV GSGFAFPSAS SLKNPPPRSN LAGIASEFPG MCIENSVSSY
QHLPCCGKLH FQSCHGNVHK LHQFPALQSC TPSGYFPCSE FTSGATGRLD EHIAQSELTS
HVCASPLHLS VAPSVCLKGS HYCSDCLNKP TRNSLVDAAK IWPNIPPPNT QTGPVSIPIC
NGCGTQGTGN EKSLLLASSL GKSPQKYGSP EVAVAGQVLE NLPPIGVFWD IENCSVPTGR
SAVAVVQRIR EKFFKGHREA EFICVCDISK ENKEVIQELN NCQVTVAHIN ATAKNAADDK
LRQSLRRFAD THTAPATVVL VSTDVNFALE LSDLRHRHGF RIILVHKNQA SEALLHHAHE
LVCFEEFISD LPPRLPLKMP ACHTLLYVYN LPTNRDSKSV SNRLRRLSDN CGGKVLSISG
SSAILRFLNQ ESAERAWKRM ENEDVFGNRI VVSFAPKNKE LNETKSSNFV GTEKVKSPKK
VNRSTKLCIT NKDGSDQSSG TKGSAGRGLQ SHGSVIKPTN VKSLQELCRL ESKTISRNTE
NHQEHLREIP SQNNSHAAAP VSLTTKKSGV GESSCKSSYK KETSVSRSMT NSPVDKKDKD
EAVFQVSYPS AFSKLTASRQ LSPLFVSQNC WSSRSMSPNL SNRSSPLTFN VVNHTSGTDC
PDPFANGADI QISNIDYRLS RKELQQTLQE TFSRHGKVKC VELSPHTDYQ LKATVQMENL
QEAISAVNSL HRYKIGSKRI QVSLATGAAN KSLSLLSSET VSILQDAPAC CLPMFKFTEI
YEKKFGRKLM VSDLYKLTDT VAIRDQGGGR LVCLLPSSQA RQSPLGSSQS HDGSSANCSP
IIFEELEYHE PVCKQHCLNK DVIEHEFDPD SYRIPFAILS LKTFAPQVHS LLQTHEGTVP
LLSFPDCYMS EFNDLEMVPE GQGGVPLEHL ITCVPGVNIA TAQNGIKVIK WIHNKPPPPT
TVDPWLLRSK SPVGNPQLIQ FSREVIDLLK SQPSCIIPVS KFIPTYHHHF AKQCRVSDYG
YSKLMELLEA VPHVLQILGM GSKRLLTLTH RAQVKRFTQD LLKLLKSQAS KQVIVKEFLQ
AYHWCFSKDW DVTEYGVCEL ADIISEIPDT TICLSQQDNE MVICIPKRER TQEEIERTKQ
FSKEVVDLLR HQPHFRMPFS KFIPSYHHHF GRQCKLAYYG FTKLLELFEA IPEVLQVLEC
GEEKILTLTE VEQVKAVAAQ FVKLLRSQKD NCLMMSDLLS EYSKTFGYTL RLHDYDVSSV
PALMQKLCHV VKVVDTESGK QIQLINRKSL RTLTAQLLVL LMSWDGASFL SVEQLKQHYE
TIHSTSLNPC EYGFMTLTEL LKSLPYLVEV FTNGAEEEYV RLTNLYMFAK NVRSLLHTYH
YQQIFLHEFL VAYSKYTGEV LQPKAYGCNN LEELLGAIPQ VVWIKGHGHK RIVVLKNDMK
TRFSSPSFPL ADHVDDHGNQ LDDHNGHIME TPGSTSSMEL SLGTPSNAPN QTEQELLCLT
NTSPVDLLCE PVPSCLPSPQ LRPDPVVLES ADLIQFEERP VPLSEMMILT EEEKQKIVTT
AQEKLTSGSV ASSTAENTSV PPRHSSETQL NKEAMDSPAK KQHKNKVKLA ANFSLAPVTK
L
