ID   MARF1_XENTR             Reviewed;        1681 AA.
AC   B2GUN4;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Meiosis regulator and mRNA stability factor 1 {ECO:0000250|UniProtKB:Q9Y4F3};
DE   AltName: Full=Limkain-b1;
DE   AltName: Full=Meiosis arrest female protein 1 homolog {ECO:0000250|UniProtKB:Q9Y4F3};
GN   Name=marf1 {ECO:0000250|UniProtKB:Q9Y4F3}; Synonyms=lkap;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential regulator of oogenesis required for female meiotic
CC       progression to repress transposable elements and preventing their
CC       mobilization, which is essential for the germline integrity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
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DR   EMBL; AAMC01072831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC166346; AAI66346.1; -; mRNA.
DR   EMBL; BC168127; AAI68127.1; -; mRNA.
DR   RefSeq; NP_001119538.1; NM_001126066.1.
DR   AlphaFoldDB; B2GUN4; -.
DR   SMR; B2GUN4; -.
DR   STRING; 8364.ENSXETP00000052982; -.
DR   PaxDb; B2GUN4; -.
DR   GeneID; 733745; -.
DR   KEGG; xtr:733745; -.
DR   CTD; 9665; -.
DR   Xenbase; XB-GENE-990483; marf1.
DR   eggNOG; ENOG502QUYZ; Eukaryota.
DR   HOGENOM; CLU_002701_0_0_1; -.
DR   InParanoid; B2GUN4; -.
DR   OMA; NNGHIME; -.
DR   OrthoDB; 187067at2759; -.
DR   TreeFam; TF329117; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:1905762; F:CCR4-NOT complex binding; IBA:GO_Central.
DR   GO; GO:1903231; F:mRNA base-pairing post-transcriptional repressor activity; IBA:GO_Central.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0016441; P:post-transcriptional gene silencing; IBA:GO_Central.
DR   CDD; cd12255; RRM1_LKAP; 1.
DR   CDD; cd12256; RRM2_LKAP; 1.
DR   Gene3D; 3.30.420.610; -; 6.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR041966; LOTUS-like.
DR   InterPro; IPR024768; Marf1.
DR   InterPro; IPR045602; MARF1_LOTUS.
DR   InterPro; IPR034189; MARF1_RRM1.
DR   InterPro; IPR034191; MARF1_RRM2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR021139; NYN_MARF1.
DR   InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR14379; PTHR14379; 2.
DR   Pfam; PF11608; Limkain-b1; 1.
DR   Pfam; PF19687; MARF1_LOTUS; 1.
DR   Pfam; PF01936; NYN; 1.
DR   Pfam; PF12872; OST-HTH; 5.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS51644; HTH_OST; 8.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Differentiation; Meiosis; Oogenesis; Peroxisome; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..1681
FT                   /note="Meiosis regulator and mRNA stability factor 1"
FT                   /id="PRO_0000417529"
FT   DOMAIN          340..477
FT                   /note="NYN"
FT   DOMAIN          779..858
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          863..937
FT                   /note="HTH OST-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          991..1067
FT                   /note="HTH OST-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1087..1161
FT                   /note="HTH OST-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1163..1238
FT                   /note="HTH OST-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1247..1321
FT                   /note="HTH OST-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1323..1398
FT                   /note="HTH OST-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1399..1472
FT                   /note="HTH OST-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          1474..1548
FT                   /note="HTH OST-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   REGION          576..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1637..1662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1637..1652
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1681 AA;  187771 MW;  DB907C12461C8F01 CRC64;
     MEGNETANLC SKSVGWLQKQ DKDVEPWLWK LSNCFSTLTQ SLPSAGGNPK DYMEHPKPKV
     ELKDVPPPPP PVKPCKNIFP TVPLPKIQPP ALPAVQHQTG PKVSCCVLCS NSTSCAPEIR
     CSGGGYIHPN TILDTGTVTC QVAPGLSFAP ESPFKKASST STFVPRSAGF SNLCLENRLS
     PCQCHSQPAP CYSKVHLNPF HGDHPRFQVP ALGTSPSYFT SGLSQHVENH LAQSEYLSHY
     CTSSLHFNTP SSAFLKGPHF CNVCFEKPSS SKVTDSHKIW PNIPPPNTSS APIPICNGCG
     TQETVKEAAL ILAKNLCKAS QKYGSPDLAT GQMQENLPPI GVFWDIENCS VPSGRSAVTV
     VKRIRERLFK GHREAEFICV CDISKENKEV IEELNNCQVT VAHINATAKN AADDKLRQSL
     RRFADTHTSP ATVVLVSTDV NFALELSDLR HRHSFHIILI HKNQASEALL HHAHELIHFE
     EFISDLPPRL PIKMQQCQTL LYVYNLPTNR DAKSISNRLR RLSDNCGGKV MSISGTSAIL
     RFANQESAER AQKRMENEDV FGNRITVSFT PRNKEVNETK NSCVSNEKAK SPKKVNKNTK
     LCLSIKDDSS SNTKAASKSA CGSVSKNSNV KSLKELCQMQ SKSNKTSQQE KDKKRNGDKQ
     GTLSQSSPLC TNQMLQTARN VGTDNTASKS FQKRDDTTRK SNADSQKEQK NKEDVVFQIS
     NPSAFSKLTE SRQASPFCSS QSGWSSRSLS PSLSNCSSPI ATNQTGAADN SVDPFANGAD
     IQIGNLDYRM SRKELQQTLH DIFSRHGKIK NVELSPHTDY QLKATVQMEN LQEAICAVNS
     LHRYKIGSKR IQVSLATGAT NKSLSLLSFG TVSILQDAPA CCLPLFKFTE IYEKKFGHKL
     IVSDLYRLTD TVTIRDQGNG RLVCLLPSVQ ARQSPMGSSQ SHDGSSANCS PVVFEELEYH
     EPICRRHCSN RKFSGHDFDP DSYIIPFVII SLKTFAPQVH SLLQTHEGTV PLLSFPDCYA
     AEFSALKEVQ EGQGGVPLEH LITCIPGVNI AFAQNGIKVV KWIHNKPPPP NSDPWLLRSK
     SPVGNPQLIQ FSREVIDLLK NQPSCIMPVT KFIPTYHHHF AKQCRVSDYG YSKLLELLEA
     VPHVLQILGM GSKRLLTLTH RAQVKRFTQD LLKLLKSQAS KQVIVREFSQ AYHWCFSRDW
     NVTEYGVCDL VDIVSEIPDT TICVSQQDGE SVISIPKRER TPEEVERTKQ FSKEVVDLLR
     HQPHFRMPFN KFIPSYHHHF GRQCKLTYYG FTKLLDLFEA IPDVLQVLEC GEEKILALTE
     MERIKALASQ LVKLLRSQKD SSINMPDLLT EYSKTFGYSL RLHDYDVSSV PALMQKLCHV
     VKIMDTDLGK QIQLINRKSL RSLTAQLLIL LMSWDESSSL TVEQLCQVYQ SVHGIPLNPC
     EYGFVSLAEL LKSLPYLVEV HTNDLCEDSV QLTSLYVFAK NVRSLLHTYH YQQIFLHEFP
     NAYSKYVGEV LQPKQYGYSS LEEILGAIPQ VVWIKGHGHK RIVVLKNDMK VCHQMDKELL
     CLTSPMDLLC GPVPSCLPSP QLHPDPVVTQ PADLIQFEEH FHFSDLVYPE ETQYNPLCNG
     TQPCNFPTSA DLDTFSEPST QNICPQESKS TKELPESPVK RQHRNRVKLA ANFSFAPVTK
     L