ID   MARR_SALTI              Reviewed;         144 AA.
AC   P0A2T5; Q56069; Q8Z702;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Multiple antibiotic resistance protein MarR;
GN   Name=marR; OrderedLocusNames=STY1540, t1441;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Repressor of the marRAB operon which is involved in the
CC       activation of both antibiotic resistance and oxidative stress genes.
CC       Binds to the marO operator/promoter site (By similarity).
CC       {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO69083.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD01793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL513382; CAD01793.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014613; AAO69083.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_455960.3; NC_003198.1.
DR   RefSeq; WP_000843434.1; NZ_WSUR01000006.1.
DR   AlphaFoldDB; P0A2T5; -.
DR   SMR; P0A2T5; -.
DR   STRING; 220341.16502638; -.
DR   EnsemblBacteria; AAO69083; AAO69083; t1441.
DR   KEGG; stt:t1441; -.
DR   KEGG; sty:STY1540; -.
DR   PATRIC; fig|220341.7.peg.1549; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_083287_18_5_6; -.
DR   OMA; YEATMVT; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..144
FT                   /note="Multiple antibiotic resistance protein MarR"
FT                   /id="PRO_0000054363"
FT   DOMAIN          11..144
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   144 AA;  16229 MW;  6923357904365440 CRC64;
     MKSTSDLFNE IIPLGRLIYM VNQKKDRLLN NYLSPLDITA TQFKVLCSIR CAGCITPVEL
     KKVLSVDLGA LTRMLDRLLC KGWIERLPNP NDKRGVLVKL TPDGAAICEQ CHQRPGQDLH
     QELTKNLTAD EVATLEYLLK KILP