ID   MARR_SALTY              Reviewed;         144 AA.
AC   P0A2T4; Q56069; Q8Z702;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Multiple antibiotic resistance protein MarR;
GN   Name=marR; OrderedLocusNames=STM1520;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=X3181;
RX   PubMed=9068629; DOI=10.1128/jb.179.6.1857-1866.1997;
RA   Sulavik M.C., Dazer M., Miller P.F.;
RT   "The Salmonella typhimurium mar locus: molecular and genetic analyses and
RT   assessment of its role in virulence.";
RL   J. Bacteriol. 179:1857-1866(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Repressor of the marRAB operon which is involved in the
CC       activation of both antibiotic resistance and oxidative stress genes.
CC       Binds to the marO operator/promoter site.
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DR   EMBL; U54468; AAC44976.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20439.1; -; Genomic_DNA.
DR   PIR; T11756; T11756.
DR   RefSeq; NP_460480.1; NC_003197.2.
DR   RefSeq; WP_000843434.1; NC_003197.2.
DR   AlphaFoldDB; P0A2T4; -.
DR   SMR; P0A2T4; -.
DR   STRING; 99287.STM1520; -.
DR   PaxDb; P0A2T4; -.
DR   EnsemblBacteria; AAL20439; AAL20439; STM1520.
DR   GeneID; 1253038; -.
DR   KEGG; stm:STM1520; -.
DR   PATRIC; fig|99287.12.peg.1608; -.
DR   HOGENOM; CLU_083287_18_5_6; -.
DR   OMA; YEATMVT; -.
DR   PhylomeDB; P0A2T4; -.
DR   BioCyc; SENT99287:STM1520-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   4: Predicted;
KW   Antibiotic resistance; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..144
FT                   /note="Multiple antibiotic resistance protein MarR"
FT                   /id="PRO_0000054364"
FT   DOMAIN          11..144
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   144 AA;  16229 MW;  6923357904365440 CRC64;
     MKSTSDLFNE IIPLGRLIYM VNQKKDRLLN NYLSPLDITA TQFKVLCSIR CAGCITPVEL
     KKVLSVDLGA LTRMLDRLLC KGWIERLPNP NDKRGVLVKL TPDGAAICEQ CHQRPGQDLH
     QELTKNLTAD EVATLEYLLK KILP