MAS1L_HUMAN
ID MAS1L_HUMAN Reviewed; 378 AA.
AC P35410; Q5SUN5;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Mas-related G-protein coupled receptor MRG;
DE Short=MAS-R;
DE AltName: Full=MAS1-like;
GN Name=MAS1L; Synonyms=MRG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1723144; DOI=10.1210/mend-5-10-1477;
RA Monnot C., Weber V., Stinnakre J., Bihoreau C., Teutsch B., Corvol P.,
RA Clauser E.;
RT "Cloning and functional characterization of a novel mas-related gene,
RT modulating intracellular angiotensin II actions.";
RL Mol. Endocrinol. 5:1477-1487(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; S78653; AAB21255.1; -; Genomic_DNA.
DR EMBL; AL035542; CAB44503.1; -; Genomic_DNA.
DR EMBL; BX000531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX247947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03197.1; -; Genomic_DNA.
DR EMBL; BC069127; AAH69127.1; -; mRNA.
DR EMBL; BC069345; AAH69345.1; -; mRNA.
DR EMBL; BC101176; AAI01177.1; -; mRNA.
DR EMBL; BC101177; AAI01178.1; -; mRNA.
DR CCDS; CCDS4661.1; -.
DR PIR; A39485; A39485.
DR RefSeq; NP_443199.1; NM_052967.2.
DR AlphaFoldDB; P35410; -.
DR SMR; P35410; -.
DR BioGRID; 125516; 1.
DR STRING; 9606.ENSP00000366331; -.
DR ChEMBL; CHEMBL4523857; -.
DR GlyGen; P35410; 2 sites.
DR BioMuta; MAS1L; -.
DR DMDM; 547920; -.
DR jPOST; P35410; -.
DR PaxDb; P35410; -.
DR PeptideAtlas; P35410; -.
DR PRIDE; P35410; -.
DR Antibodypedia; 2949; 172 antibodies from 30 providers.
DR DNASU; 116511; -.
DR Ensembl; ENST00000377127.4; ENSP00000366331.3; ENSG00000204687.4.
DR Ensembl; ENST00000383549.3; ENSP00000373041.2; ENSG00000206470.3.
DR Ensembl; ENST00000383643.3; ENSP00000373139.2; ENSG00000206515.3.
DR Ensembl; ENST00000415802.3; ENSP00000405164.2; ENSG00000233141.3.
DR Ensembl; ENST00000418003.3; ENSP00000410649.2; ENSG00000234954.3.
DR Ensembl; ENST00000420035.3; ENSP00000405030.2; ENSG00000228377.3.
DR Ensembl; ENST00000449044.3; ENSP00000399042.2; ENSG00000228515.3.
DR Ensembl; ENST00000451019.3; ENSP00000392071.2; ENSG00000237284.3.
DR GeneID; 116511; -.
DR KEGG; hsa:116511; -.
DR MANE-Select; ENST00000377127.4; ENSP00000366331.3; NM_052967.2; NP_443199.1.
DR CTD; 116511; -.
DR DisGeNET; 116511; -.
DR GeneCards; MAS1L; -.
DR HGNC; HGNC:13961; MAS1L.
DR HPA; ENSG00000204687; Tissue enhanced (cervix, epididymis).
DR MIM; 607235; gene.
DR neXtProt; NX_P35410; -.
DR OpenTargets; ENSG00000204687; -.
DR PharmGKB; PA134912067; -.
DR VEuPathDB; HostDB:ENSG00000204687; -.
DR eggNOG; ENOG502SNTZ; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_2_1; -.
DR InParanoid; P35410; -.
DR OMA; ACVIFLK; -.
DR OrthoDB; 849624at2759; -.
DR PhylomeDB; P35410; -.
DR TreeFam; TF336336; -.
DR PathwayCommons; P35410; -.
DR BioGRID-ORCS; 116511; 11 hits in 1064 CRISPR screens.
DR GeneWiki; MAS1L; -.
DR GenomeRNAi; 116511; -.
DR Pharos; P35410; Tbio.
DR PRO; PR:P35410; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P35410; protein.
DR Bgee; ENSG00000204687; Expressed in smooth muscle tissue and 42 other tissues.
DR ExpressionAtlas; P35410; baseline and differential.
DR Genevisible; P35410; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..378
FT /note="Mas-related G-protein coupled receptor MRG"
FT /id="PRO_0000069717"
FT TOPO_DOM 1..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..101
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..136
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..169
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..207
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..248
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 344..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 288
FT /note="D -> E (in dbSNP:rs17184100)"
FT /id="VAR_049416"
SQ SEQUENCE 378 AA; 42411 MW; E08A606294B61474 CRC64;
MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETNETI
HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV
IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW
YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC
VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS
LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS
TQHVENLLPR EHRVDVET
