ID   MASP1_AGEPP             Reviewed;          14 AA.
AC   P69436;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Agelaia-MPI {ECO:0000303|PubMed:30974767};
DE   AltName: Full=Agelaia-MP {ECO:0000303|PubMed:15052574, ECO:0000303|PubMed:15225564};
OS   Agelaia pallipes pallipes (Neotropical social wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Agelaia.
OX   NCBI_TaxID=313352;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-14, FUNCTION, MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=15052574; DOI=10.1002/rcm.1382;
RA   Mendes M.A., Monson de Souza B., Delazari dos Santos L., Palma M.S.;
RT   "Structural characterization of novel chemotactic and mastoparan peptides
RT   from the venom of the social wasp Agelaiapallipes pallipes by high-
RT   performance liquid chromatography/electrospray ionization tandem mass
RT   spectrometry.";
RL   Rapid Commun. Mass Spectrom. 18:636-642(2004).
RN   [2]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-14, SYNTHESIS, FUNCTION, MASS
RP   SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=15225564; DOI=10.1016/j.toxicon.2004.04.009;
RA   Mendes M.A., de Souza B.M., Marques M.R., Palma M.S.;
RT   "Structural and biological characterization of two novel peptides from the
RT   venom of the neotropical social wasp Agelaia pallipes pallipes.";
RL   Toxicon 44:67-74(2004).
RN   [3]
RP   FUNCTION, AND BIOTECHNOLOGY.
RX   PubMed=30974767; DOI=10.3390/toxins11040216;
RA   das Neves R.C., Mortari M.R., Schwartz E.F., Kipnis A.,
RA   Junqueira-Kipnis A.P.;
RT   "Antimicrobial and antibiofilm effects of peptides from venom of social
RT   wasp and scorpion on multidrug-resistant Acinetobacter baumannii.";
RL   Toxins 11:0-0(2019).
CC   -!- FUNCTION: Antibacterial peptide (PubMed:30974767). Inhibits biofilm
CC       formation of A.baumannii and Staphylococcus spp. bacteria
CC       (PubMed:30974767). Also shows potent mast cell degranulation activity
CC       and potent hemolytic activity of rat erythrocytes (PubMed:15052574,
CC       PubMed:15225564). Does not show chemotaxis for polymorphonucleated
CC       leukocytes (PMNL) (PubMed:15052574, PubMed:15225564).
CC       {ECO:0000269|PubMed:15052574, ECO:0000269|PubMed:15225564,
CC       ECO:0000269|PubMed:30974767}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15052574,
CC       ECO:0000269|PubMed:15225564}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15052574, ECO:0000305|PubMed:15225564}.
CC   -!- MASS SPECTROMETRY: Mass=1565.0; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15052574};
CC   -!- MASS SPECTROMETRY: Mass=1565.25; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15225564};
CC   -!- BIOTECHNOLOGY: Could be used to treat biofilm-resistant agents such as
CC       A.baumannii and Staphylococcus spp. coated on the surfaces of implanted
CC       medical devices, such as vascular stents.
CC       {ECO:0000269|PubMed:30974767}.
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013214; Mastoparan_peptide.
DR   Pfam; PF08251; Mastoparan_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Hemolysis; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Agelaia-MPI"
FT                   /evidence="ECO:0000269|PubMed:15052574,
FT                   ECO:0000269|PubMed:15225564"
FT                   /id="PRO_0000044051"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:15052574,
FT                   ECO:0000269|PubMed:15225564"
SQ   SEQUENCE   14 AA;  1568 MW;  2209239FC7F1FE38 CRC64;
     INWLKLGKAI IDAL