ID   MAST1_PROEX             Reviewed;          14 AA.
AC   P69034;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Mastoparan-1 {ECO:0000305};
DE   AltName: Full=Mastoparan I {ECO:0000303|PubMed:15581688};
DE            Short=MP-I {ECO:0000303|PubMed:15581688};
OS   Protopolybia exigua (Neotropical social wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Protopolybia.
OX   NCBI_TaxID=91439;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SYNTHESIS, MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, AND AMIDATION AT LEU-14.
RC   TISSUE=Venom;
RX   PubMed=15581688; DOI=10.1016/j.toxicon.2004.09.015;
RA   Mendes M.A., de Souza B.M., Palma M.S.;
RT   "Structural and biological characterization of three novel mastoparan
RT   peptides from the venom of the neotropical social wasp Protopolybia exigua
RT   (Saussure).";
RL   Toxicon 45:101-106(2005).
CC   -!- FUNCTION: Mast cell degranulating peptide. Has hemolytic activity. Its
CC       both activities may be due to pore formation.
CC       {ECO:0000269|PubMed:15581688}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15581688}. Target
CC       cell membrane {ECO:0000305|PubMed:15581688}. Note=Forms a membrane
CC       channel in the prey. {ECO:0000305|PubMed:15581688}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15581688}.
CC   -!- MASS SPECTROMETRY: Mass=1581.02; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15581688};
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013214; Mastoparan_peptide.
DR   Pfam; PF08251; Mastoparan_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Mast cell degranulation; Membrane; Secreted; Target cell membrane;
KW   Target membrane; Toxin; Transmembrane.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan-1"
FT                   /evidence="ECO:0000269|PubMed:15581688"
FT                   /id="PRO_0000044055"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:15581688"
SQ   SEQUENCE   14 AA;  1583 MW;  2204A4FA356F1E38 CRC64;
     INWLKLGKKV SAIL