MAST2_PROEX
ID MAST2_PROEX Reviewed; 14 AA.
AC P69035;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 23-FEB-2022, entry version 26.
DE RecName: Full=Mastoparan-2 {ECO:0000305};
DE AltName: Full=Mastoparan II {ECO:0000303|PubMed:15581688};
DE Short=MP-II {ECO:0000303|PubMed:15581688};
OS Protopolybia exigua (Neotropical social wasp).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Polistinae; Epiponini; Protopolybia.
OX NCBI_TaxID=91439;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, SYNTHESIS, MASS SPECTROMETRY, SUBCELLULAR
RP LOCATION, AND AMIDATION AT LEU-14.
RC TISSUE=Venom;
RX PubMed=15581688; DOI=10.1016/j.toxicon.2004.09.015;
RA Mendes M.A., de Souza B.M., Palma M.S.;
RT "Structural and biological characterization of three novel mastoparan
RT peptides from the venom of the neotropical social wasp Protopolybia exigua
RT (Saussure).";
RL Toxicon 45:101-106(2005).
CC -!- FUNCTION: Mast cell degranulating peptide. Activates G proteins (Gi
CC component), which in turn activates the cascade of molecular events
CC cAMP-regulated, resulting in mast cell degranulation.
CC {ECO:0000269|PubMed:15581688}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15581688}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:15581688}.
CC -!- MASS SPECTROMETRY: Mass=1566.90; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:15581688};
CC -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Mast cell degranulation; Secreted.
FT PEPTIDE 1..14
FT /note="Mastoparan-2"
FT /evidence="ECO:0000269|PubMed:15581688"
FT /id="PRO_0000044056"
FT MOD_RES 14
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:15581688"
SQ SEQUENCE 14 AA; 1569 MW; 10509B37AA71F610 CRC64;
INWKAIIEAA KQAL