ID   MASTC_VESMG             Reviewed;          40 AA.
AC   A0SPI0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Mastoparan-like peptide 12c;
DE   Flags: Precursor;
OS   Vespa magnifica (Hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=202807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-39, FUNCTION, MINIMAL
RP   INHIBITORY CONCENTRATION, AMIDATION AT LEU-39, AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=17046111; DOI=10.1016/j.peptides.2006.09.003;
RA   Xu X., Yang H., Yu H., Li J., Lai R.;
RT   "The mastoparanogen from wasp.";
RL   Peptides 27:3053-3057(2006).
CC   -!- FUNCTION: Shows mast cell degranulation and antimicrobial activities
CC       against the Gram-negative bacteria E.coli ATCC 25922 (MIC=6.0 ug/ml),
CC       the Gram-positive bacteria S.aureus ATCC 2592 (MIC=3.0 ug/ml) and the
CC       fungus C.albicans ATCC 2002 (MIC=12 ug/ml).
CC       {ECO:0000269|PubMed:17046111}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1479.9; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:17046111};
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ865260; ABI94579.1; -; mRNA.
DR   AlphaFoldDB; A0SPI0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013213; Mastoparan.
DR   Pfam; PF08249; Mastoparan; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Mast cell degranulation; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:17046111"
FT   PEPTIDE         26..39
FT                   /note="Mastoparan-like peptide 12c"
FT                   /id="PRO_0000305121"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:17046111"
SQ   SEQUENCE   40 AA;  3983 MW;  BE7DF85716BA807B CRC64;
     MSAEALADPK ADPLAGPNPD ADPEAINLKA IAALAKKLLG