ID   MASTD_VESMG             Reviewed;          14 AA.
AC   P0C5G7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Mastoparan-like peptide 12d;
OS   Vespa magnifica (Hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=202807;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MINIMAL INHIBITORY CONCENTRATION, AMIDATION AT
RP   LEU-14, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=17046111; DOI=10.1016/j.peptides.2006.09.003;
RA   Xu X., Yang H., Yu H., Li J., Lai R.;
RT   "The mastoparanogen from wasp.";
RL   Peptides 27:3053-3057(2006).
CC   -!- FUNCTION: Shows mast cell degranulation and antimicrobial activities
CC       against the Gram-negative bacteria E.coli ATCC 25922 (MIC=3.0 ug/ml),
CC       the Gram-positive bacteria S.aureus ATCC 2592 (MIC=1.5 ug/ml) and the
CC       fungus C.albicans ATCC 2002 (MIC=12.0 ug/ml).
CC       {ECO:0000269|PubMed:17046111}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1495.9; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:17046111};
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013213; Mastoparan.
DR   Pfam; PF08249; Mastoparan; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing;
KW   Fungicide; Hemolysis; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan-like peptide 12d"
FT                   /id="PRO_0000306370"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:17046111"
SQ   SEQUENCE   14 AA;  1498 MW;  C85A7ECA1D7AB0DD CRC64;
     INLKAIAAMA KKLL