ID   MASTI_POLPI             Reviewed;          14 AA.
AC   P0C1Q4; P84878;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   23-FEB-2022, entry version 21.
DE   RecName: Full=Mastoparan-1;
DE   AltName: Full=Mastoparan I;
DE            Short=MPI;
DE   AltName: Full=Polybia-MPI {ECO:0000303|PubMed:16129513};
DE   AltName: Full=Venom protein MP-1;
OS   Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Polybia.
OX   NCBI_TaxID=291283;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AMIDATION AT LEU-14, MINIMAL
RP   INHIBITORY CONCENTRATION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=16129513; DOI=10.1016/j.peptides.2005.04.026;
RA   Souza B.M., Mendes M.A., Santos L.D., Marques M.R., Cesar L.M.M.,
RA   Almeida R.N.A., Pagnocca F.C., Konno K., Palma M.S.;
RT   "Structural and functional characterization of two novel peptide toxins
RT   isolated from the venom of the social wasp Polybia paulista.";
RL   Peptides 26:2157-2164(2005).
CC   -!- FUNCTION: Chemotactic peptide for polymorphonucleated leukocytes
CC       (PMNL), but causing no hemolysis to rat erythrocytes and no mast cell
CC       degranulation activity at physiological concentrations. Potent
CC       antimicrobial peptide against Gram-positive bacteria B.subtilis CCT
CC       2576 (MIC=4 ug/ml), and S.aureus ATCC 6538 (MIC=15 ug/ml) and Gram-
CC       negative bacteria E.coli ATCC 25922 (MIC=8 ug/ml) and P.aeruginosa ATCC
CC       15422 (MIC=8 ug/ml). {ECO:0000269|PubMed:16129513}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16129513}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:16129513}.
CC   -!- MASS SPECTROMETRY: Mass=1654.09; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16129513};
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   TCDB; 1.C.118.1.1; the mastoparin peptide 1 (mpp1) family.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   GO; GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Chemotaxis;
KW   Direct protein sequencing; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan-1"
FT                   /evidence="ECO:0000269|PubMed:16129513"
FT                   /id="PRO_0000247263"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:16129513"
SQ   SEQUENCE   14 AA;  1655 MW;  5504B937A2D3F7A7 CRC64;
     IDWKKLLDAA KQIL