ID   MASTR_BOVIN             Reviewed;         430 AA.
AC   A7E346;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=MEF2-activating motif and SAP domain-containing transcriptional regulator;
DE   AltName: Full=MEF2-activating SAP transcriptional regulatory protein;
GN   Name=MAMSTR; Synonyms=MASTR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-430.
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator. Stimulates the transcriptional
CC       activity of MEF2C. Stimulates MYOD1 activity in part via MEF2,
CC       resulting in an enhancement of skeletal muscle differentiation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MEF2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AAFC03027484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151712; AAI51713.1; -; mRNA.
DR   RefSeq; NP_001181940.1; NM_001195011.1.
DR   RefSeq; XP_005219251.1; XM_005219194.2.
DR   RefSeq; XP_005219252.1; XM_005219195.2.
DR   RefSeq; XP_010813311.1; XM_010815009.2.
DR   AlphaFoldDB; A7E346; -.
DR   SMR; A7E346; -.
DR   STRING; 9913.ENSBTAP00000015429; -.
DR   PaxDb; A7E346; -.
DR   PRIDE; A7E346; -.
DR   Ensembl; ENSBTAT00000015429; ENSBTAP00000015429; ENSBTAG00000011617.
DR   Ensembl; ENSBTAT00000077689; ENSBTAP00000070193; ENSBTAG00000011617.
DR   Ensembl; ENSBTAT00000084765; ENSBTAP00000057014; ENSBTAG00000011617.
DR   GeneID; 505540; -.
DR   KEGG; bta:505540; -.
DR   CTD; 284358; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011617; -.
DR   VGNC; VGNC:31160; MAMSTR.
DR   eggNOG; ENOG502RJE6; Eukaryota.
DR   GeneTree; ENSGT00940000154181; -.
DR   HOGENOM; CLU_055830_0_0_1; -.
DR   InParanoid; A7E346; -.
DR   OMA; PKISQHW; -.
DR   OrthoDB; 1127316at2759; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000011617; Expressed in corpus luteum and 98 other tissues.
DR   ExpressionAtlas; A7E346; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0010831; P:positive regulation of myotube differentiation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   Pfam; PF02037; SAP; 1.
DR   SMART; SM00513; SAP; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
DR   PROSITE; PS50800; SAP; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..430
FT                   /note="MEF2-activating motif and SAP domain-containing
FT                   transcriptional regulator"
FT                   /id="PRO_0000319980"
FT   DOMAIN          181..215
FT                   /note="SAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT   REGION          84..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..430
FT                   /note="Transcription activation"
FT                   /evidence="ECO:0000250"
FT   REGION          280..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           12..28
FT                   /note="MEF2-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        130..169
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  46215 MW;  E91D646B7AC61387 CRC64;
     MTLAASSQRS QIIRSKFRSV LQLRIHRRYQ DPTLSGSFTA SPVLDPDPWI SAADPALALA
     PASPLGPAPF LFNPEVLLPE PKPCWSLKKE SPKTSQHWRE PKPKGNLTYH QYIPPEPRQG
     YRADPQVEGS PLDPPGPPLW EGTTSQQPPP RMKPTPLTPS PPGVPSPSPL PHKLELQTLK
     LEELTVSELR QQLRLRGLPV SGTKSMLLER MRGGAPPRER PKARREDSAA GAPWPRFRPK
     ALGAARSACS FKLSPTSHSP PPPRAVETLV TASASAPVPV ATTAQAPTPA PVPVPSSAPA
     STALTLEEEL QEAIRRAQLL PNRGIDDILE DQVEPEDPLP AIPLDFPGSF DMLSPSPDSE
     GLSSVFSSSL PSPTNSPSPS PRGPTDFLDW LEALSGGPSL GCGPPAPSIF SADLSDSSGT
     RLWDLLEDPW