ID   MAST_PARID              Reviewed;          14 AA.
AC   P42716;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Mastoparan;
DE            Short=MP;
OS   Parapolybia indica (Lesser paper wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Ropalidiini; Parapolybia.
OX   NCBI_TaxID=31921;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT ILE-14, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RA   Toki T., Yasuhara T., Nakajima T.;
RT   "Isolation and sequential analysis of peptides on the venom sac of
RT   Parapolybia indica.";
RL   Eisei Dobutsu 39:105-111(1988).
RN   [2]
RP   HEMOLYTIC ACTIVITY.
RX   PubMed=15581688; DOI=10.1016/j.toxicon.2004.09.015;
RA   Mendes M.A., de Souza B.M., Palma M.S.;
RT   "Structural and biological characterization of three novel mastoparan
RT   peptides from the venom of the neotropical social wasp Protopolybia exigua
RT   (Saussure).";
RL   Toxicon 45:101-106(2005).
CC   -!- FUNCTION: Mast cell degranulating peptide. Activates G proteins that
CC       couple to phospholipase C. Has hemolytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   TCDB; 1.C.32.1.1; the amphipathic peptide mastoparan (mastoparan) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013213; Mastoparan.
DR   Pfam; PF08249; Mastoparan; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Mast cell degranulation; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000044053"
FT   MOD_RES         14
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   14 AA;  1619 MW;  CA376CD3BA6D80DD CRC64;
     INWKKMAATA LKMI