ID   MAST_VESMA              Reviewed;          14 AA.
AC   P04205;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   02-JUN-2021, entry version 52.
DE   RecName: Full=Mastoparan-M;
DE   AltName: Full=Mast cell-degranulating peptide;
OS   Vespa mandarinia (Asian giant hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=7446;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-14.
RC   TISSUE=Venom;
RA   Hirai Y., Yasuhara T., Yoshida H., Nakajima T.;
RT   "A new mast cell degranulating peptide, mastoparan-M, in the venom of the
RT   hornet Vespa mandarinia.";
RL   Biomed. Res. 2:447-449(1981).
CC   -!- FUNCTION: Mast cell degranulating peptide. Activates G proteins that
CC       couple to phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the MCD family. Mastoparan subfamily.
CC       {ECO:0000305}.
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DR   PIR; A01777; QMVHMM.
DR   TCDB; 1.C.32.1.4; the amphipathic peptide mastoparan (mastoparan) family.
DR   PRIDE; P04205; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR013213; Mastoparan.
DR   Pfam; PF08249; Mastoparan; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Mastoparan-M"
FT                   /id="PRO_0000044061"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   14 AA;  1480 MW;  C85A7ECA1D7B00DD CRC64;
     INLKAIAALA KKLL